There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Het is voor scholen in toenemende mate een forse uitdaging om uitval van docenten op te vangen. Het lerarentekort benadrukt het belang van een ondersteunende werkomgeving en sterke binding tussen docent en school.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

De programmagroep Onderwijswetenschappen heeft expertise op het gebied van het levenslang lerende individu in het onderwijs, met veel aandacht voor lerende kinderen.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Software development is a complex process. It is important that software products become stable and maintainable assets.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Op donderdag 9 november is Reijer Passchier gepromoveerd op zijn proefschrift over ‘informal constitutional change’. Zijn promotor is Professor Wim Voermans.

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

This thesis covers various applications of topology in condensed matter physics and quantum information.

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa

Veel belangrijke onderwerpen in de informatica, zoals de juistheid van software, de efficiëntie van algoritmen en de modellering van gecompliceerde systemen, zijn afhankelijk van een goede theoretische onderbouwing. In de Theoriegroep bestuderen we deze fundamentele bouwstenen en ontwikkelen we verificatiemethoden…

Onder vindt u de wetenschappelijke publicaties van het Navigatie Lab Leiden

In de onderzoekslijn 'Dierwetenschappen en gezondheid' werken we met verschillende diersoorten om meer te weten te komen over fundamentele biologische processen in dier én mens.

Een onderzoek naar de rol van familieleden bij processen van uitreizen naar en terugkeren uit buitenlandse jihdistische strijdgroepen.

De bachelor Biologie houdt zich bezig met de levende natuur. Zo bestudeer je het leven op cellulair- en moleculair niveau en verdiep je onder andere in de diversiteit van planten en dieren.

In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

What holds people together and what makes them willing to fit within larger political structures? Our project examines this question in the practices of dynastic rulership in Eurasia ca. 1300-1800.

De studie Bio-Farmaceutische Wetenschappen richt zich specifiek op geneesmiddelenontwikkeling. Je bestudeert de (bij)werking van geneesmiddelen en kijkt naar de mechanismen van ziektes.

Met de bachelorspecialisatie Informatica & Economie aan de Universiteit Leiden leer je waardevolle inzichten in de economie te combineren met (programmeer)vaardigheden en kennis uit de informatica.

How were the Russians, under early modern conditions, able to incorporate this distant, undeveloped and, because frequent nomadic attacks, dangerous territory? And what role did the Kolyvan-Voskresensk plants play in this process?

In Nederland leggen niet alleen strafrechters straffen op. Ook het Openbaar Ministerie en overheden zijn bevoegd om straffen uit te delen. Leidse experts onderzoeken hoe deze processen van bestraffing verlopen en kunnen worden verbeterd, onder meer om de rechtspositie van burgers te beschermen.

Misinformatie over gezondheidskwesties, zoals voedingssupplementen en anticonceptie, wordt een steeds grotere zorg voor zorgprofessionals. Dit kan leiden tot gezondheidsrisico’s en een verhoogde druk op de gezondheidszorg.