526 zoekresultaten voor “break make” in de Publieke website
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Luttinger liquid on a lattice
Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.
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Unconventional fabrication of 2D nanostructures and graphene edges
In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.
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Tail Regeneration in the Tokay Gecko (Gekko gecko)
Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.
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Unraveling modular architecture and domain engineering of carbohydrate-active enzymes: key insights for sustainable bio-based processes
This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…
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Rebel with a cause: The effects of leadershipencouragement and psychological safety onprofessionals' prosocial rulebreaking behavior
Dit artikel onderzoekt aanmoediging door leiderschap en psychologische veiligheid als antecedenten van prosociaal regelovertredend gedrag (PSRB).
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New dimensions of the cellular response to DNA damage
Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.
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Life In Plastic, Not Always Fantastic: Nano- and microplastics and their impact on terrestrial plants and the food chain
Plastics have become an integral part of modern society due to their versatility and durability.
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Separating quantum and classical computing: rigorous proof and practical application
This thesis probes under what conditions quantum computing presents an advantage over classical computing.
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Some Assembly Required: The Structural Evolution and Mass Assembly of Galaxies at z
This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.
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Quantifying nucleosome dynamicsand protein binding with PIE-FCCS and spFRET
In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…
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Realising the right to reproduce with assistance in South Africa
Op 10 november 2021 verdedigde Carmel van Niekerk-Jacobs het proefschrift 'Realising the right to reproduce with assistance in South Africa'. Het promotieonderzoek is begeleid door prof.dr. J.J. Sloth-Nielsen en prof.dr. T. Liefaard.
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Verba Africana
The project
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Breaking the Ice: Constraining the volatile distribution in protoplanetary disks
Promotie
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Breaking barriers: unraveling response mechanisms to immunotherapy in breast cancer
Promotie
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Nascholingsdag World Teachers Programme 2024
World Teachers Festival 2024 - Celebrating and exploring language, culture, diversity and criticality in teaching and learning
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia
Op 23 juni 2020 verdedigde Santy Kouwagam haar proefschrift 'How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. C.E. von Benda-Beckmann.
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Design and development of a comprehensive data management platform for cytomics: cytomicsDB
Promotor: Prof.dr. J.N. Kok
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The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
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Signalling pathways that control development and antibiotic production in streptomyces
Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.
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Gender and transnationalism: Moroccan migrants and their descendants in the Netherlands, 1965-2000
Deelproject van
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Electroextraction approaches for preconcentration of metabolites
In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.
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Sofia Express
In Sofia Express gaat Jan Paul Hinrichs op zoek naar de literaire geheimen van de Bulgaarse hoofdstad Sofia, een stad waarin detectives, spionage en andere intriges nooit ver weg zijn.
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Chemistry and Biotechnology for Sustainability
If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Vergroten van Biodiversiteit op de Campus
Kijk regelmatig op deze pagina voor meer informatie over het vergroten van de biodiversiteit aan de Universiteit Leiden.
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Latest hardware for computer research on medical imaging
The LIACS Media Lab has received a research grant from the worldwide leading graphics hardware company NVIDIA. The grant exists of newly developed hardware utilizing thousands of processors. LIACS researchers will use it to investigate deep learning in understanding imagery from sources such as MRI…
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Designing 'context-specific' regional innovation policy: a study on the role of regional government in six European regions
Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Spatio-temporal aspects of antigen cross-presentation in dendritic cells: with click-to-release chemistry
The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.
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Large scale visual search
Promotor: J.N. Kok, Co-promotor: M.S. Lew
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Improving robustness of tomographic reconstruction methods
Promotor: Prof.dr. K.J. Batenburg
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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The noisy underwater world: the effect of sound on behaviour of captive zebrafish
Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn
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Electrical and magnetic properties of ferritin: electron transport phenomena and electron paramagnetic resonance
Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.
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Cryptography from quantum uncertainty in the presence of quantum side information
Promotor: Ronald Cramer, Co-promotor: Serge Fehr
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Exploring structure dependencies of gas-surface interactions with curved single crystals
Curved single crystals provide variable, but well-defined surface structures.
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Chemical Similarity: Structuring Risk and Hazard Assessment
At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Patterned detectors: From design to science
Patterned detectors are an existing technology that can be found in almost all color cameras.
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Infrared spectroscopy of astrophysically relevant hydrocarbons
This thesis is about the study of hydrocarbons via infrared spectroscopy.
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A new method to reconstruct the structure from crystal images
Promotor: J.P. Abrahams, Co-promotor: T. Grüne
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Lights in a sea of darkness: constraining the nature and properties of dark matter using the stellar kinematics in the centres of ultra-faint
Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.
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Getting personal: Advancing personalized oncology through computational analysis of membrane proteins
Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.
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Suppressing a Sea of Starlight: Enabling technology for the direct imaging of exoplanets
Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik