Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

Promotor: V. Vitelli, Co-promotor: J. Paulose

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Promotor: Prof.dr. B. van de Water

Prof.dr. J. Memelink

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Promotores: K.J. Batenburg, B. Koren

Hoe motiveert een open leeromgeving studenten en welke factoren stimuleren student agency?

Promotor: F. Arbab

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotor: R. Gill, Co-promotor: P. Massart

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Promotores: T.H. Oosterkamp, N. de Jonge

In this thesis the links between allergy and intestinal health, the gut microbiome (GM), and external factors were studied by exploring the metabolome in longitudinal clinical studies and in vitro models.

Congres/symposium

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Wil je de bacheloropleiding Midden-Oostenstudies volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Wil je de bacheloropleiding Oude Nabije Oostenstudies volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Wil je de bacheloropleiding Latijns-Amerikastudies volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Wil je de bacheloropleiding Koreastudies volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Wil je de bacheloropleiding Chinastudies volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Wil je de bacheloropleiding Duitse taal en cultuur volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Wil je de bacheloropleiding Japanstudies volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Wil je de bacheloropleiding Midden-Oostenstudies volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Wil je de bacheloropleiding Midden-Oostenstudies volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Wil je de bacheloropleiding Nederlandse taal en cultuur volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Wil je de bacheloropleiding Griekse en Latijnse taal en cultuur volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Wil je de bacheloropleiding Geschiedenis volgen aan de Universiteit Leiden? Controleer dan allereerst wat de toelatingseisen zijn van de opleiding:

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.