Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: J.N. Kok, Co-promotor: M.S. Lew

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Wil je een volledige academische opleiding? Dan ga je na je bachelor door met een masteropleiding. Met een masterdiploma op zak heb je meer kans op een baan op academisch niveau. Na afronding krijg je de titel Master of Arts (MA).

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotor: K.J. Batenburg

Cardiovascular disease is the leading cause of death worldwide.

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

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De IgNobel prijs wordt jaarlijks uitgereikt aan tien onderzoeken die je ‘eerst laten lachen en daarna aan het denken zetten’. Wetenschappers uit de hele wereld kijken reikhalzend uit naar (het winnen) van die onderscheiding.

Check hieronder de aanmelddeadlines voor de opleiding Biologie.

De Leidse masterstudent Arend Moerman heeft een tien gekregen voor zijn afstudeeronderzoek naar de simulatie van de chaotische interacties van drie zwarte gaten. Uit de simulaties blijkt dat lichtere zwarte gaten elkaar meestal wegslingeren, terwijl zwaardere vooral samensmelten. Het onderzoek, een…

Met haar project WetSuite wil Meuwese AI-technieken die gebruikt kunnen worden om juridische overheidsdocumenten te analyseren toegankelijk maken voor een brede groep onderzoekers.

‘Hoe ziet mijn eerste collegemaand eruit?’ en ‘Wat zijn de beste plekjes om te wonen in Leiden?’ Op vrijdag 5 juni konden zo’n 80 aankomende studenten van de opleidingen Biologie en Natuurkunde nog voor de allerlaatste keer vragen stellen over hun toekomstige studie. Beide Meet Leiden Science events…

Lezing, Lezingenreeks vergelijkende Indo-Europese taalwetenschap (VIET)

Check de volgende toelatingseisen voordat jij je aanmeldt voor de opleiding Biologie.

Experimentele technieken maken het mogelijk de piepkleine onderdelen van de mens als biologisch systeem in kaart te brengen: het DNA, de eiwitten, de cellen. Maar hoe vormen al die radertjes samen eigenlijk een mens? Wiskundig bioloog prof.dr. Roeland Merks helpt biologen de mens weer in elkaar te zetten.…

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Biologiestudente Britt van Kasterop heeft een Jong Talent aanmoedigingsprijs van de Koninklijke Hollandsche Maatschappij der Wetenschappen ontvangen voor haar uitmuntende resultaten in het eerste studiejaar. De online prijsuitreiking vond plaats op 30 november.