Het nieuwe kabinet dreigt bijna een miljard euro te bezuinigen op het hoger onderwijs. Dit brengt niet alleen het werk op de universiteit in gevaar, dit is een ramp voor Nederland zelf. De geplande langstudeerboete en andere financiële maatregelen zullen studenten zwaar treffen en de toegankelijkheid…

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Tijdens de vroege moderne tijd werden veel middeleeuwse manuscripten in stroken perkament gesneden, die opnieuw werden gebruikt om de bindingen van nieuw gedrukte boeken te versterken. Tot voor kort kwamen deze hergebruikte stukjes middeleeuwse manuscripten alleen aan het licht wanneer de vroege moderne…

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Dit project ontwikkelt een wetenschappelijke methode om klinisch relevante nieuwe informatie te extraheren uit patiëntenforum-websites die ervaringen van patiënten bespreken over bv. medicatie, voeding, co-morbiditeiten, genetische factoren enz.

De Faculty of Governance and Global Affairs

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

In dit project bundelen onderzoekers en docenten van LUCAS, het ICLON en de UBL de krachten om expertise en ervaring op het gebied van machine learning en AI als open leermateriaal voor het middelbaar onderwijs te publiceren.

In digitale archieven liggen ongelooflijk veel archeologische rapporten opgeslagen. Wie daar informatie in wil zoeken, moet dat vaak handmatig doen. En dat is echt monnikenwerk. Archeoloog Alex Brandsen heeft nu met deep learning, een vorm van kunstmatige intelligentie, een zoekmachine ontwikkeld die…

We moeten onze data en informatie opslaan op een manier die de computer begrijpt. Dat zegt Barend Mons, hoogleraar Biosemantiek bij het Leids Universitair Medisch Centrum en voorzitter van de High Level Expert Group for the European Open Science Cloud. We praten met hem over FAIR data, knowlets en n…

In november 2020 is het Engelstalige boek ‘Financial Collateral; Law and Practice’ verschenen. Het boek is gepubliceerd door Oxford University Press en geredigeerd en geschreven door professor Matthias Haentjens. Voorts hebben meegeschreven Anthony Zacaroli (High Court, Chancery Division), Yael Diamant…

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

In this thesis, we study systems of electrons in which strong correlations give rise to emergent exotic physics.

Promotor: E.F. Smets, Co-promotor: J. Geml

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

A new publication on changes in the relationship between news and their public in Chile

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

In light of climate change, it is crucial to determine whether plant species can adapt to future climates to avoid extinction. Plants adapt to various conditions by altering their functional traits, such as leaf size or photosynthetic rate. Some traits appear linked and vary together between species,…

Promotor: J.N. Kok, Co-promotor: M.S. Lew

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Onderzoek van de sectie Methodologie & Statistiek van het Instituut Psychologie aan de Universiteit Leiden

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Prof.dr. J. Memelink

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Promotor: Prof.dr. B. van de Water

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.