This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

All the data stored and processed by our computers is encoded as sequences of zeros and ones, called bits. Quantum computers offer an alternative to this traditional way of encoding and manipulating information.

Lorenza Colzato wil onderzoeken of het gebruik van probiotica en tryptofaan de sociaal-cognitieve achteruitgang die optreedt bij het ouder worden, kan vertragen. Daarvoor ontvangt Colzato samen met haar collega's in Duitsland en Spanje een JPI 'A Healthy Diet for A Healthy Life' Joint Transnational…

Het thema 'Health and well-being in a healthy society' is één van de speerpunten van de Faculteit der Sociale Wetenschappen (FSW). We zetten ons in voor het bevorderen van gezondheid en welzijn voor mensen van alle leeftijden.

Ontdek de cursus Extremisme, Desinformatie en Vijandige Staten van het Centre for Professional Learning en leer over de actualiteiten. Lees hier meer!

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Op dinsdag 24 maart is het boek 'The European Public Servant: A shared Administrative Identity?' verschenen.

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotor: Prof.dr. P. Stevenhagen

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

Kunst en vrije tijd, Kunst en vrije tijd

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Het boek gaat in op de vraag: Hoe en waarom raken mensen betrokken bij het Europese 'homegrown jihadisme'?

Congres/symposium

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Het Leiden University Centre for the Arts in Society (LUCAS) is wereldwijd een van de weinige onderzoeksinstituten waar wetenschappers op het gebied van literatuur, beeldende kunst, architectuur, design en mediastudies samenkomen om onderzoek te doen naar de culturele productie van de westerse wereld,…

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Op vrijdag 13 en zaterdag 14 september 2024 vond de jaarlijkse bijeenkomst van de European Group of Public Law (EGPL) plaats in Legrena, Griekenland.

Promotor: H.W. Lenstra

Promotor: R. Tijdeman

De invloed van politiek gevoelige zaken op publiek vertrouwen in rechters

Celebrating 20 years of Environmental Research and Education in Northern Cameroon

Promotie

Boek over de totstandkoming van het Koninkrijk der Nederlanden, onder redactie van onder andere Henk te Velde.

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs