Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Promotor: J. A. Bouwstra

Studievoorlichting

Optimally solving real-world expensive Black-Box Optimization (BBO) problems w.r.t. real-world constraints, such as wall-clock time and computational costs, is extremely difficult and tedious.

Op 9 april promoveert Manolis Fragkiadakis. Het Leiden University Centre for Linguistics feliciteert Manolis!

Het centrale doel van dit proefschrift is inzicht verschaffen in hoe de implementatie van een peer educator-interventie van invloed kan zijn op de houding van leerlingen tegenover LHBT-leeftijdgenoten en op de relatie tussen deze houdingen en reflectie over burgerschap.

De auteur onderzocht waarom bureaucraten vluchtelingen integreren in welzijnsvoorzieningen, zelfs als ze daartoe geen wettelijke verplichting hebben.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Understanding how chemical complexity emerges during star formation requires connecting molecular material preserved in interstellar ices with that observed in the gas phase after protostellar heating begins.

Op 12 december promoveert Ria Huijgen-Koolen. Het Leiden University Centre for Linguistics feliciteert Ria!

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotor: A.P.IJzerman Co-promotor: A. Bender

Op 29 Juni 2017 heeft Doris Dull-Zessner haar proefschrift “Value Congruence in a Multinational Corporation” verdedigd. De supervisors zijn prof.dr.mr. J.A.A. Adriaanse and prof.dr. J.I. van der Rest.

Veel docenten in het voortgezet onderwijs houden rekening met verschillen tussen leerlingen. Uit het promotieonderzoek van Saskia Stollman (ICLON) blijkt dat zij hierbij ruimte om te experimenteren en ondersteuning van de school(leiding) nodig hebben.

Wout Broekema benadrukt dat organisaties niet alleen leren van crises, maar ook vergeten, waarbij cruciale kennis en werkwijzen verloren gaan.

This dissertation presents four separate chapters, all striving towards the same goal: to understand dynamic phenomena occurring in dynamic networks and to explore the emergence of equilibrium in a broad sense.

Individuen die werken in de publieke sector zien zichzelf geconfronteerd worden met tegenstrijdige waarden, tegenstrijdige eisen en de noodzaak van het dienen van het soms moeilijk definieerbare publieke belang.

Deze praktische gids informeert studenten over de taal en andere vaardigheden die nodig zijn om een presentatie in het Engels te geven. Deze bondige en toegankelijke gids is bijzonder behulpzaam voor leerders van het Engels.

In this dissertation, we study partition-based models that can be used both for interpretable predictive modeling and for understanding data via interpretable patterns.

Lezing, Boeklancering

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Dit is een praktische handleiding gericht op promovendi, Research Master studenten en early-career researchers uit alle vakgebieden. De instructies in de gids zijn bedoeld als inspiratie voor jonge onderzoekers en als hulp om Open Science te beoefenen door hun onderzoek zo open als mogelijk te delen…

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

The increasing competition in the automotive industry requires the tailored, swift development of technologically sophisticated vehicles. Therefore, the computationally expensive state-of-the-art simulation technologies are combined with optimization algorithms. An example of a real-world optimization…

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.