Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

In this dissertation, we study partition-based models that can be used both for interpretable predictive modeling and for understanding data via interpretable patterns.

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Promotor: B. van de Water

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Meer informatie over dit onderzoeksproject vind je op de Engelstalige pagina.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

Op 29 januari 2019 verdedigde Robbert van Eijk proefschrift 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. Het promotieonderzoek is begeleid door promotor prof. dr. H.J. van den Herik.

Ter voorbereiding op toekomstige wettelijke hervormingen op het gebied van gendergerelateerd geweld in de Republiek Moldavië werd Carlotta Rigotti door het United Nations Population Fund uitgenodigd om deel te nemen aan een rondetafelgesprek over wetgevings- en beleidsbenaderingen voor online en door…

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Carlotta Rigotti, postdoctoraal onderzoeker bij eLaw – Centrum voor Recht en Digitale Technologie, en professor Clare McGlynn van Durham University hebben samen een nieuw artikel gepubliceerd in de Oxford Journal of Legal Studies, waarin zij het concept meta-verkrachting introduceren en de mogelijke…

In dit onderzoek worden orde isomorfismen en orde antimorfisme bestudeerd in het algemene kader van partieel geordende vector ruimten.

Anika Bexkens is niet alleen hoogleraar maar ook werkzaam als klinisch psycholoog en psychotherapeut in de geestelijke gezondheidszorg. Zij ziet een kloof tussen wetenschap en praktijk, die zij in haar oratie probeert te overbruggen.

Dit artikel onderzoekt de integratie van scenariogebaseerd leren (SBL) in een cursus crisiscommunicatie om de praktische vaardigheden en reflectie van studenten in echte situaties te verbeteren.

SAFEandSOUND heeft de ambitie om de beleidscyclus te verbinden met gegevens die zijn gegenereerd in robottestzones om empirisch onderbouwde beleidsvorming voor robottechnologieën te ondersteunen.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Promotor: A. Kros

Met dit project wordt onderzocht hoe docenten op drie internationale scholen zich gezamenlijk professionaliseren rond het thema ‘Inquiry based teaching’. Gegeven de rijkdom aan ervaring en achtergronden van de docenten op internationale scholen, kan worden verwacht dat docenten veel kunnen leren…

Op 26 september promoveert Cosmas Rai Amenorvi. Het Leiden University Centre for Linguistics feliciteert Cosmas!

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Hoe kan challenge-based learning in het hoger onderwijs bijdragen aan duurzaam stedelijk afvalbeheer en de transitie van Den Haag naar een zero-waste stad in 2050 ondersteunen?

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Waarom radicaliseert de ene persoon tot betrokkenheid bij terroristisch geweld binnen een groepscontext, terwijl de ander zich alleen aan deze vorm van geweld waagt? In dit artikel vergelijken Bart Schuurman en Sarah Carthy op basis van een nieuw ontwikkelde dataset terroristen in groepsverband en terroristen…

Promotor: S.M. Verduyn Lunel

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

Including modelling as part of software development appears to have various benefits.

Promotor: G.J.B. van Ommen

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.