Promotor: G.P. van Wezel

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

The focus of the dissertation

This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

Promotor: G.R. de Snoo, Co-promotor: C.J.M. Muster

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Promotores: S.F. Portegies Zwart, E. M. Rossi

This dissertation presents new cryptographic protocols, which can be divided into two families.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

This PhD thesis concerns the topic of arithmetic geometry. We address three different questions and each of the questions in some way is about counting how big some set is or can be.

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Promotores: K.J. Batenburg, B. Koren

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotores: Bas Edixhoven, Guy Henniart

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

In oktober 1740 voltrok zich in Batavia een drama waarvan de overzeese wereld een aantal maanden later met ontsteltenis kennisnam. Als reactie op een Chinese volksopstand tegen het VOC-bestuur richtten de Europese burgers van de stad samen met de matrozen van de vloot een verschrikkelijke slachting…

In this thesis we classify the pairs (p,G), where p is a prime number and G is a finite p-group possessing an intense automorphism, i.e. an automorphism that sends each subgroup of G to a G-conjugate, that is non-trivial and whose order is coprime to p.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: H.W. Lenstra

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: Bas Edixhoven, Promotor: Qing Liu

Lezing

Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Volle collegezalen, een drukbezochte informatiemarkt en een file bij de koffie in de kelder: tijdens de Open Dag werd de Faculteit Geesteswetenschappen overspoeld door nieuwsgierige studiekiezers.

John Boy en zijn collega's van het d12n-onderzoekscluster krijgen een beurs van het Digital Infrastructure Insights Fund D//F.

In de wetenschap is het van vitaal belang dat meerdere studies hetzelfde resultaat onderschrijven. Onderzoekers moeten daarom alle details van eerdere experimenten kennen om de procedures zo exact mogelijk uit te kunnen voeren. Dit is echter een steeds groter probleem in de neurowetenschappen. Het is…

Duurzame biotechnologie, nieuwe inzichten in genoomevolutie en gebundelde krachten in de wiskunde. De NWO heeft deze drie vernieuwende Leidse onderzoeksprojecten een subsidie toegekend in de Open Competitie ENW-M.

Van een Limburgse kostschool voor hoogadellijke meisjes tot de gedwongen afstand van onwettige kinderen: de nieuwe podcast ‘Open Geesten’ van de Faculteit Geesteswetenschappen van de Universiteit Leiden gaat in op de vaak vergeten positie van vrouwen in de geschiedenis. In de driedelige reeks vertellen…

Deze maand verscheen in het tijdschrift Overheid & Aansprakelijkheid een artikel van Georgina Kuipers over het vertrouwenwekkende schadebeleid rondom de aanleg van de Noord/Zuidlijn, getiteld: ‘Van tunnelvisie naar open blik. De schadevergoedingslessen van de Noord/Zuidlijn’.