248 zoekresultaten voor “mycobacteria marinus infection” in de Publieke website
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.
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Marinus MendelFaculteit der Rechtsgeleerdheid
m.m.mendel@law.leidenuniv.nl | 071 5272727
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Marinus Schouteschoute@physics.leidenuniv.nl | 071 5271892
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Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
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Marinus van IJzendoorn
Faculteit der Sociale Wetenschappen
vanijzen@fsw.leidenuniv.nl | 071 5272727
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Marinus van Hekken
Marinus van Hekken is promovendus bij het Instituut voor Geschiedenis.
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Illuminating Host Defence against Mycobacterial Infection: Interactions with Autophagy and LC3-Associated Phagocytosis
Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
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extraembryonic serosa protects the insect egg against desiccation and infection
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Dennis Bos bij Dijkstra & Evenblij ter plekke over Marinus van der Lubbe
Leidenaar Marinus van der Lubbe stak in 1933 de Rijksdag in Berlijn in brand, maar volgens universitair docent Dennis Bos was hij eigenlijk ‘een ontzettend lieve jongen’. Hij vertelde over Van der Lubbe in een aan Leiden gewijde aflevering van het radioprogramma Dijkstra & Evenblij ter plekke.
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An uncertain recovery: The physical toll of COVID-19 infection on liberal arts and sciences students in the Netherlands
Josien de Klerk en Tennessee Miller onderzochten de interactie tussen de ziekte- en herstelervaringen van studenten en de academische werkcultuur in deze context.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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The unexplored functions of Toll-like receptor signaling: Immunometabolism, development and microbiome interactions
Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Noortje Dannenberg
Tuberculose is een van de meest dodelijke ziekten ter wereld waarvoor nog steeds geen effectieve behandeling beschikbaar is. De vraag hoe de veroorzakende bacterie langdurig kan overleven in ons lichaam is nog onduidelijk. Wij hebben sterke aanwijzingen gevonden dat het verlies van de celwand hier een…
- Symposium: A Dutch Perspective on Mycobacterial Infections
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Cornelis Hokke
Cornelis H. (Ron) Hokke is hoogleraar Glycobiologie van Gastheer-Pathogeen Interactie en hoofd van de subafdeling LUCID Research van het Leids Universitair Medisch Centrum
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Bart Roep
Dr. Bart O. Roep is hoogleraar in de Diabetologie, Immunopathologie & Interventie en director van het National Diabetes Expertise Centrum van het Leids Universitair Medisch Centrum, en Visiting Professor van de Danish Diabetes Academy. Hij is ook Founding Chair en Professor of Medicine van de Afdeling…
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Voeden met vet: hoe mycobacteriële infecties de vetten in ons lichaam benutten
Hoe gebruiken ziekteverwekkende mycobacteriën de vetten in onze cellen, en hoe kunnen we dat tegenhouden?
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From stress to success; How actinobacteria exploit live without a cell wall
The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
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Global metabolomics and lipidomics approaches to probe virus-host interactions
The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.
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LUF subsidie voor tuberculoseonderzoek bij het Instituut Biologie Leiden
Prof. Herman P. Spaink heeft een subsidie gekregen om te screenen voor nieuwe geneesmiddelen tegen tuberculose. Deze subsidie voor de verdere ontwikkeling van robottechnologie voor grootschalige geneesmiddelenscreening was mogelijk dankzij donaties van Leidse alumni.
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.
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How nutrient conditions shape antibiotic sensitivity in Pseudomonas aeruginosa
The impact of the phenotypic plasticity of P. aeruginosa and the distinct CF lung microenvironments on antibiotic drug effects and resistance remains poorly understood.
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Irene Pascual Garciai.pascual.garcia@biology.leidenuniv.nl | 071 5272727
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Mechanisms of vaccines against viral infections
Promotie
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Leiden Consortium on Individual Development (L-CID)
Waarom zijn niet alle kinderen even gevoelig voor variaties in hun sociale omgeving?
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Cluster International Relations and European Politics
International Relations and European Politics is one of the three organisational clusters of the Institute of Political Science.
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Cluster Security and Legitimacy
Security and Legitimacy is one of the three organisational clusters of the Institute of Political Science.
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Gezondheid en ziekte van de luchtwegen in Nederland
Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).
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Cornelis van Kooten
Cees van Kooten is hoogleraar experimentele nefrologie, i.h.b. de immunologie van transplantatie, hoofd van het immunologisch laboratorium van de sectie nierziekten van de afdeling interne geneeskunde en onderdeel van het Einthoven laboratorium voor vasculaire en regeneratieve geneeskunde. Hij is voorzitter…
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Comparative biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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Expanding the chemical space of antibiotics produced by Paenibacillus and Streptomyces
Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…