Promotores: A.H. Meijer, H.P. Spaink

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: Prof.dr. J.N. Kok

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotie

Leidenaar Marinus van der Lubbe stak in 1933 de Rijksdag in Berlijn in brand, maar volgens universitair docent Dennis Bos was hij eigenlijk ‘een ontzettend lieve jongen’. Hij vertelde over Van der Lubbe in een aan Leiden gewijde aflevering van het radioprogramma Dijkstra & Evenblij ter plekke.

Josien de Klerk en Tennessee Miller onderzochten de interactie tussen de ziekte- en herstelervaringen van studenten en de academische werkcultuur in deze context.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Tuberculosebacteriën overleven door zich te verstoppen in onze afweercellen. In haar promotieonderzoek kijkt bioloog Salomé Muñoz Sánchez hoe we het afweersysteem kunnen helpen deze dodelijke bacterie te slim af te zijn. Ze ontdekte dat twee specifieke eiwitten in onze afweercellen een sleutelrol spelen…

Hoe gebruiken ziekteverwekkende mycobacteriën de vetten in onze cellen, en hoe kunnen we dat tegenhouden?

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Control of infectious diseases poses continuous challenges for human health.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Prof. Herman P. Spaink heeft een subsidie gekregen om te screenen voor nieuwe geneesmiddelen tegen tuberculose. Deze subsidie voor de verdere ontwikkeling van robottechnologie voor grootschalige geneesmiddelenscreening was mogelijk dankzij donaties van Leidse alumni.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Promotie

Waarom zijn niet alle kinderen even gevoelig voor variaties in hun sociale omgeving?

International Relations and European Politics is one of the three organisational clusters of the Institute of Political Science.

Security and Legitimacy is one of the three organisational clusters of the Institute of Political Science.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Promotores: H.A. Udo De Haes, P.M. Brakefield

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.