This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L.B.F.M. Waters (UvA), Prof.dr. C. Dominik (UvA)

My work focuses on a class of astronomical objects called protoplanetary disks.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

To study how planetary systems come into existence we study much younger systems still in formation.

This research focuses on the distribution of chemical elements in protoplanetary disks, the birthplaces of planets. These disks form around young stars and contain gas and dust, from which planets grow. Ice plays a crucial role in planet formation, aiding the clumping of dust particles and influencing…

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Promotor: Prof.dr. C.U. Keller

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

Planets are formed in disks of gas and dust around young stars.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

De Microscopy Unit huisvest, onderhoudt en coördineert vrijwel alle microscopieapparatuur van het IBL. De beschikbare apparatuur varieert van conventionele licht- en fluorescentiemicroscopen tot confocale laser- en elektronenmicroscopen. Er is bovendien apparatuur beschikbaar voor histologie, met inbegrip…

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Dit onderzoek gaat over de verschillende manieren waarop beleefdheidsvormen worden gebruikt in het Japans naast het uitdrukken van beleefdheid, en hoe verschillende factoren de perceptie van deze vormen beïnvloeden.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Het Horizon 2020 project ImageInLife is op 1 januari van start gegaan, met eind deze maand een kick-off meeting bij de coördinerende Universiteit van Montpellier. Dit Marie Skłodowska-Curie trainingsnetwerk brengt Europese groepen bij elkaar die werken aan imaging van gewervelde organismen en biedt…

Hoe breng je larven van de zebravis microscopisch in beeld? De nieuwe gratis online cursus ‘Imaging the Vertebrate embryo’ leert je er alles over. Leidse promovendi Salomé Muñoz Sánchez en Radoslaw Gora werkten mee aan de cursus.

Promovenda Femke Lokke Groeneweg onderzocht hoe onze cellen en ons lichaam omgaan met stress en wat het effect is van ontstekingsremmende medicijnen. Promotie 6 november 2014.

Een overzicht van awards en prijzen die in 2022 zijn toegekend aan onze medewerkers en studenten, maar ook bijzondere benoemingen aan de Universiteit Leiden en andere instellingen.

Veertig archeologiestudenten staan onwennig met een schep tussen de weilanden in Oss. Tijdens hun allereerste dag veldwerk gaan ze spieren aanspreken waarvan ze nog niet wisten dat die bestonden.

Instituten en onderzoeksgroepen bij elkaar brengen, hoe doe je dat? De faculteit W&N stelde een gezamenlijk onderzoeksthema in en financierde drie promotieplaatsen. Na vier jaar loopt het profileringsprogramma Endocannabinoïden af. ‘Het heeft ons echt bij elkaar gebracht, en de samenwerkingen blijven…

Tijdens de nieuwjaarsreceptie van de Faculteit der Wiskunde en Natuurwetenschappen op 6 januari 2015 is bekend gemaakt dat Annelien Zweemer, Leiden Academic Centre for Drug Research, is benoemd tot Ontdekker van het jaar 2014. Matteo Brogi, Leidse Sterrewacht, heeft het beste proefschrift van 2014 geschreven…

Orthopedagoge Marcia Goddard is de winnaar van de Nederlandse finale van de wetenschaps-communicatiewedstrijd FameLab. Ze zal Nederland in de internationale Famelab-finale vertegenwoordigen.

Voor het eerst hebben astronomen complexe organische moleculen gedetecteerd in de protoplanetaire schijf rond een jonge ster. De ontdekking, gedaan met de Atacama Large Millimeter/submillimeter Array (ALMA) in Chili, bevestigt opnieuw dat de omstandigheden waaruit aarde en zon zijn voortgekomen niet…