In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

The main aim of this project is to reveal and unravel the invisible histories of the UN, transcending the dominant Western perspective to recover the historical agency of Global South actors. The research will investigate how the UN has both facilitated and limited their role in shaping global order…

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

Het boek 'The United Nations Convention on the Rights of the Child' is het resultaat van de conferentie – ’25 Years CRC’ – die in november 2014 in Leiden werd gehouden.

Dit boek onderzoekt de impact van het VN-Verdrag inzake de Rechten van het Kind (IVRK) op nationale en internationale rechtspraak, sinds de aanname van dit verdrag in 1989. Het boek verschaft inzicht in de functies, uitdagingen en beperkingen van het IVRK in nationale, regionale en internationale juridische…

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Op 11 mei 2016 ontving het Hazelhoff Centre for Financial Law Robert Pickel voor de elfde Hazelhoff Guest Lecture, getiteld ‘The Deadliest Sin of the Financial Crisis’.

Scott Waitukaitus is namens LION genomineerd als Discoverer of the Year 2017. Breng snel je stem uit!

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Stem voor de Ontdekker van het jaar 2017! Wie van deze onderzoekers verdient volgens jou een prijs voor zijn of haar werk? Vanaf nu kan je stemmen!

Promotor: S.J. Edixhoven, L.D.J. Taelman

Hoe zetten belangenorganisaties in Nederland strategisch procederen in om politieke, maatschappelijke of juridische veranderingen te realiseren, en hoe verhoudt deze strategie zich tot andere klassieke vormen van beleidsbeïnvloeding?

Explore "Surgical anatomy of the leg in relation to nerve injuries" at Boerhaave Nascholing. Read more here.

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Promotor: Prof.dr. W.T.F. den Hollander

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Promotor: Prof.dr. A.G.G.M. Tielens

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Trui Steen, universitair hoofddocent bij het Instituut Bestuurskunde, heeft donderdag 27 november 2014 de NIG Supervisor of the Year Award 2014 gewonnen.

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Op 3 december 2019 verdedigde Meda Couzens haar proefschrift 'The application of the United Nations Convention on the Rights of the Child by national courts'. Het promotieonderzoek is begeleid door promotoren prof.dr. T. Liefaard en prof.mr. J.J. Sloth-Nielsen.

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

Promotor: Prof.dr. M. Ubbink

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: K.H. Kuijken

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.