Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

De universitair hoofddocent bij het Instituut voor Fiscale en Economische vakken is per 1 oktober 2023 een van de twee promovendidecanen van de Faculteit der Rechtsgeleerdheid.

A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

Exoplanets close in to their host star receive high levels of extreme ultraviolet (EUV) irradiation, capable of heating and ultimately driving the hydrodynamic escape of their atmospheres.

Promotor: S.M. Verduyn Lunel

We consider the propagation of electrical signals through nerve fibres.

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

What is leadership? Can it be taught, and if so, how? The International Leiden Leadership Programme (ILLP) helps students find their own style, say ILLP graduate Marko Simovski and his former coach Annah Neve in an interview: 'It’s about you, discovering you.'

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.

Promotie

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

Students Practicing Citizen Journalism

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Hybrid Symposium: Medieval miniatures from Byvanck to the RKD. 18 March 2025, Den Haag.

On 28 September, the Medieval Murder Maps website will be shared publicly for the first time. The makers have used fourteenth-century coroners' rolls to map the homicides in three medieval towns: London, York, and Oxford. These digital maps are interactive and come with podcasts of interesting cases,…

Na het ontvangen van je diploma van LUC, kun je als alumni overal ter wereld heen. Velen die je voor zijn gegaan hebben ervoor gekozen om een master als vervolgopleiding te doen. Sommigen beginnen meteen aan hun professionele carrière of volgen een PhD. Door de vele academische vakgebieden die op LUC…

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

Op 12 januari 2022 verdedigde Mirjam Franke het proefschrift 'Over de grens van de onrechtmatige daad'. Het promotieonderzoek is begeleid door prof.mr. A.G. Castermans en prof.mr. J.H. Crijns.

CML-IA is a database that contains characterisation factors for life cycle impact assessment (LCIA) and is easily read by the CMLCA software program.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.