Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: Prof.dr. S.F. Portegies Zwart

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Promotores: W. Jiskoot, F. Ossendorp

This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

Van systeembiologische modellering een centrale pijler van het onderzoek in de biologie maken.

This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

In this thesis, single-cell approaches were applied to characterize the impact of aging on the immunological B cell landscape in different models of atherosclerotic cardiovascular disease, with the goal to identify and study new B cell-associated biomarkers and therapeutic targets to halt atherosclerosis…

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

Promotie

Promotie

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotor: Prof.dr. M. Ubbink

Promotie

Promotor: S.M. Verduyn Lunel

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.