In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

Bij Cambridge University Press (CUP) verscheen onlangs van Ingrid Leijten het boek Core Socio-Economic Rights and the European Court of Human Rights. Het boek maakt onderdeel uit van de serie Cambridge Studies in European Law and Policy en heeft als onderwerp de bescherming van sociaaleconomische rechten…

The thesis describes the development, synthesis and biological evaluation of several proteasome inhibitor designs. Mainly, this work focusses on designing proteasome inhibitors that selectively inhibit the immunoproteasome, while leaving the constitutive proteasome mostly, if not completely, untouch…

The Encyclopedia of Global Human Migration biedt een complete verkenning van de prominente thema's, gebeurtenissen en theoretische onderbouwingen van de verplaatsingen van menselijke bevolkingsgroepen van de prehistorie tot heden.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

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Op vrijdag 24 februari zal Prof. Judith Masson (Bristol University), Hoogleraar Rechtssociologie en Fellow bij the UK Academy of Social Science, een lezing geven binnen de Leiden Socio-Legal Series.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Curved single crystals provide variable, but well-defined surface structures.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

In deze dissertatie onderzoekt Galikyan hoe de multidimensionaliteit van gegevens over interactie tussen studenten en de veelzijdigheid van deze interactie van invloed zijn op de meting van interactie tussen studenten in digitale leeromgevingen.

The overarching goal of this PhD thesis is to investigate the taxonomic and functional diversity of yeasts in the wheat phyllosphere and their interactions with the mycotoxigenic fungal pathogen Fusarium graminearum.

Promotie

Hoe kunnen we op een interdisciplinaire wijze de classificatie van migranten en mensen met een beperking bestuderen en onderzoekers van deze velden samenbrengen om raakvlakken met elkaar te vinden?

Op dinsdag 23 mei 2017 verdedigde Jasmina Mackic haar proefschrift ‘Proving discriminatory violence at the European Court of Human Rights’. De promotor is vice-decaan en hoogleraar internationaal publiekrecht Larissa van den Herik. Hieronder volgt een korte samenvatting van haar proefschrift.

Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.

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Op 18 juni 2019 verdedigde Peter Kempees zijn proefschrift 'Hard power and the European Convention on Human Rights'. Het promotieonderzoek is begeleid door promotoren prof. dr. R.A. Lawson en prof. dr. H. Duffy.

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

Het mededingingsrecht zorgt ervoor dat bedrijven op een eerlijke wijze concurreren. De Nederlandse Autoriteit Consument & Markt (ACM) handhaaft het mededingingsrecht in Nederland en kan bedrijven die oneerlijk concurreren bestraffende en herstellende maatregelen opleggen. Deze bedrijven hebben, wanneer…

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

Promotie

A recent study on reintroduced tigers in Panna Tiger Reserve in India reveals that risks from tigers increased more because of human behaviour and people's livestock husbandry practices.

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Studievoorlichting, On Campus Experience

Studievoorlichting, On Campus Experience

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

In dit artikel bespreken Joachim Koops en Christian Patz de uitgebreide beoordeling van de Duitse gereedheid op het gebied van 'Protection of Civilians' (PoC).

Dit proefschrift betreft een interpretatief onderzoek naar de wijze waarop leraren hun dagelijkse leraar-leerling interacties interpreteren in termen van het belang van hun leerlingen.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

Exploring the Meanings of Lands and Forests as an Avenue for Mutual Development of People and Nature in Ghana

De geesteswetenschappen beslaan een groot wetenschappelijk vakgebied, maar wat is eigenlijk de gemene deler van al deze wetenschappers en studenten? En waarom doet hun werk ertoe in de wereld van vandaag? Bekijk de trailer van Humans of Humanities, de nieuwe documentaire over de Leidse Faculteit Geesteswetenschappen.…