The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Denk je aan geesteswetenschappen, denk je misschien niet meteen aan een nieuwe superserver. Toch is die inmiddels net in gebruik genomen. Universitair docent Jelena Prokic van het Centre for Digital Humanities vertelt meer over deze ontwikkeling.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Cristina Grasseni’s project

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Webinar met Q&A

Why do sexual violence policies still fail to systematically address men and masculinities, when the need for cultural change among men has been central in public debates since #MeToo?

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.

Promotor: Prof.dr. M. Ubbink

Dit project onderzoekt de professionalisering van universiteitsbibliotheken in de negentiende en vroege twintigste eeuw, door de lens van het middeleeuwse handschriftenbezit. Met de Leidse Universiteitsbibliotheek als uitgangspunt werpt het licht op de veranderende praktijken rond het conserveren, behandelen…

Het Leiden University Centre for Digital Humanities (LUCDH) heeft per 1 februari een nieuwe directeur. Universitair hoofddocent Angus Mol wil in zijn nieuwe rol mensen en kennis verbinden.

Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Promotor: P.D. Grünwald

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

In this thesis,

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

In the first part of this thesis we study the geometry of folding patterns.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

In my research, we developed a method to distinguish knots. A knot is a mathematical depiction of the everyday knot that occurs in ropes and cords.

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

This thesis studies the geometry of representation varieties and character stacks. These are spaces parametrizing the representations of a finitely generated group, typically the fundamental group of a compact manifold, into an algebraic group G.

This thesis covers various applications of topology in condensed matter physics and quantum information.

Oude UB, Rapenburg 70, 2311 EZ, Leiden

Lipsius, Cleveringaplaats 1, 2311 BD, Leiden

FSW-gebouw, Wassenaarseweg 52, 2333 AK, Leiden

Wijnhaven, Turfmarkt 99, 2511 DP, Den Haag

Gorlaeus Gebouw, Einsteinweg 55, 2333 CC, Leiden

Kamerlingh Onnes Gebouw, Steenschuur 25, 2311 ES, Leiden