Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

In this study, we investigated the electrochemical behavior and surface evolution of Au(111) electrode under different conditions and electrochemical techniques, using a homemade electrochemical scanning tunneling microscope (EC-STM), revealing the intricate interplay between surface roughening, atom…

What holds people together and what makes them willing to fit within larger political structures? Our project examines this question in the practices of dynastic rulership in Eurasia ca. 1300-1800.

Van onderwijs tot een verrijkende ervaring

Students Practicing Citizen Journalism

Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…

Kunst en vrije tijd, Kunst en vrije tijd

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

In this thesis,

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

What is the current relevance of the ethics of counterterrorism and what is the added value of ethics support within the practice of counterterrorism?

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

This thesis is about the study of hydrocarbons via infrared spectroscopy.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.

Promotor: Prof.dr. C.W.J. Beenakker

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

The project Multimedia Research and Documentation of African Oral Genres: Connecting Diasporas and Local Audiences (Director: D.Merolla) focuses on multimedia as technology that allows scholars to share documentation and scientific knowledge with the cultural owners of the collected oral genres.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Promotores: Wim Jiskoot; Ferry Ossendorp

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

De meeste kinderen leren pas op de middelbare school Frans. Hoe leuk is het als ze al wat Franse woorden leren en kennismaken met de Franse cultuur op de basisschool? Dat kan via deze kennismakingslessen, gemaakt door studenten van de Universiteit Leiden.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Heart failure is a major health care problem with high mortality.

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

Fundamental research in the ALgebra, Geometry And Number Theory

Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Combinatorial games are games for two competing players, moving in a turn-by-turn fashion, in which there is no chance nor hidden information⁠. Chess, checkers and the simpler tic tac toe are well-known examples of this class of games, as well as game of go⁠.

Promotores: G.W. Canters, T.J. Aartsma

This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.