This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Promotor: Roeland M.H. Merks

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Archeologie

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…

Promotor: Prof.dr. J.N. Kok

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Biologie in perspectief

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Kies voor de bacheloropleiding Biologie aan de Universiteit Leiden als je geïnteresseerd bent in het begrijpen van levende processen. Je doet kennis op om biologische toepassingen te vinden voor problemen in de maatschappij.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Gefascineerd door Biologie en benieuwd wat Universiteit Leiden jou te bieden heeft? Je ziet het in de opleidingsvideo.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Leraar biologie worden? Haal je eerstegraads onderwijsbevoegdheid via de lerarenopleiding van de Universiteit Leiden en word docent in het voortgezet onderwijs.

Promotor: Prof.dr. H.V.J. Linnartz

Relaties zijn voor mensen een biologische noodzaak. En in tijden van crisis neemt die noodzaak alleen maar toe. Al vroeg in de ontstaansgeschiedenis van de mens waren hormonen betrokken bij de omgang en het gevoel van verbondenheid met onze medemensen. In het boek 'Verbonden' legt Peter Bos uit hoe…

Kan het gif van slangen, schorpioenen en andere dieren leiden tot nieuwe antibiotica?

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Nu het steeds beter lukt om de moleculaire gegevens van cellen en weefsels te ontsluiten, schept dat ook direct een nieuwe uitdaging. Want hoe vind je uit die enorme hoeveelheid data de juiste informatie voor onderzoek?

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Op zaterdag 30 mei werd de Biologie Olympiade Junior afgesloten met een feestelijke prijsuitreiking in het Kamerling Onnes Gebouw door Prof. Edgar Groenen.

Promotor: S.J. Edixhoven, L.D.J. Taelman

This thesis introduces the concept of

Het Natuurwetenschappelijk Gezelschap Leiden (NGL) vierde op vrijdag 24 april 2015 haar 145 jarig bestaan met een lustrumexcursie naar het Instituut voor Biologie Leiden (IBL), Universiteit Leiden. Hier kregen de leden en gasten, waaronder veel alumni, een kijkje achter de schermen van het instituut…

Pas als we stap voor stap een plant of dier kunnen ‘bouwen’, begrijpen we hoe het organisme werkt. Zo kunnen we volgen en invoelen hoe eiwitten en DNA zich organiseren tot cellen en hoe cellen zich logischerwijs wel moeten organiseren tot weefsels, organen en hele dieren. Pas dan begrijpen we echt hoe…

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Een team van Leidse en Delftse studenten Life Science&Technology (LST), Nanoscience en Bio-informatica werkt hard aan een bacterie-estafetterace waarmee het de strijd aanbindt in de iGEM-competitie.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Bent u zoekende hoe u modelleren een rol kan geven binnen uw biologieonderwijs? Vind u modelleren leuk, wilt u uw kennis delen en halen hoe u modellen kunt koppelen aan voor leerlingen aansprekende contexten? De steunpunten bieden een PLG Modelleren in de Biologie aan, waar nog vijf plaatsen voor beschikbaar…

This thesis describes the importance of being able to control the selectivity of potential drug candidates.