Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Het chemische biologie-onderzoek bij het Leids Instituut voor Chemisch Onderzoek (LIC) is gericht op het begrijpen van biologische processen op moleculair niveau, om zo onze kennis te vergroten over gezondheid en ziekte van de mens.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Overkleeft

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

De Universiteit Leiden houdt haar drinkwaterverbruik zo laag mogelijk.

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Water is all around us and is vital for all aspects of life. Studying the various compounds and life forms that inhabit natural waters lets us better understand the world around us.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

The International Course on Water Use and Management in Cagayan Valley The Philippines (2011-2015)

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

This thesis examines the impacts and challenges of water use of electric power system. This thesis found that there are large differences in water use of electricity technologies, with hydropower and thermal power being two large water users.

Nederland telt een achttal echte eilanden, of negen als ‘Rottum’ (Rottumeroog en Rottumerplaat) voor twee wordt gerekend. Daarnaast zijn er zeventien voormalige eilanden, waar de sfeer van vroeger nog voelbaar is. Jan Bank en Doeko Bosscher, fervente eilandliefhebbers, onderzoeken de geschiedenis van…

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

Op 18 januari is de studie ‘Stille wateren hebben diepe gronden – Een analyse van de inkomensverdeling en haar determinanten over de afgelopen veertig jaar’ verschenen. Op deze website kunnen de studie en het achterliggend cijfermateriaal geraadpleegd worden.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Door menselijke invloeden, bijvoorbeeld vervuiling, kunnen levende watersystemen gaan wankelen. Dat heeft niet alleen gevolgen voor de biodiversiteit, maar ook voor functies als waterzuivering. De Universiteit Leiden brengt levende watersystemen in kaart met de modernste technieken.

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

The upscaling of Life Cycle Assessment (LCA) data is recognized as one of the main challenges in the ex-ante LCA of emerging technologies. This challenge arises since industrial-scale system specifications for these technologies are unknown and industrial data is lacking.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.