Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.

This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…

Promotor: Prof.dr.ir. E. Deprettere

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Jan Sleutels is een Universitair hoofddocent aan het Instituut voor Wijsbegeerte.

Promotor: H.V.J. Linnartz

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Promotores: Prof.dr. M.K. Richardson, Prof.dr. H.P. Spaink. Co-promotor: C.P. Bagowski

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Voor groep 5/6 basisschool.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Promotor: A.P. IJzerman

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: B.van de Water, Co-promotor: L.S.Price

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Wat heeft het onderzoek opgeleverd?

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

Op 23 oktober 2019 verdedigde Yoram Stein zijn proefschrift 'Spinoza's Theory of Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society'. Het promotieonderzoek is begeleid door promotor prof.dr. P.B. Cliteur en prof.dr. A.A.M. Kinneging.

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Wie een breed beeld van Afrika wil hebben, moet in Leiden zijn. Aan de hand van taal en cultuur, geschiedenis, antropologie en sociologie, verdiepen we ons in de landen, inwoners en maatschappij van dit continent. Vanuit dit perspectief werken we aan mondiale thema's als migratie, erfgoed en kolonia…

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Marietje Beemsterboer verdedigde haar proefschrift op 12 juni 2018.

Heb je interesse om Latijns-Amerikastudies te komen studeren aan de Universiteit Leiden? Om je een indruk te geven het leven als student, vertelt Marilein Forrer, eerstejaarsstudente over een typische dag.

Ben jij een nieuwsgierige en enthousiaste student en wil je meer naast je studie doen? Dan is het honoursonderwijs misschien wel iets voor jou.

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Promotor: Prof.dr. E. F. van Dishoeck

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Terrorisme destabiliseert regeringen, ondermijnt de burgermaatschappij, bedreigt sociale en economische ontwikkeling, brengt democratie in gevaar en heeft een directe impact op mensenrechten. De buitengewone gebeurtenissen op 9/11 veranderden terrorismebestrijding in een wereldwijd bestuursproject.…

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Griekse en Latijnse taal en cultuur studeren in Leiden? Kom studeren bij Universiteit Leiden! Bekijk de opleidingsvideo voor meer informatie.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)