The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

Prof.dr. J. Memelink

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Cardiovascular disease is the leading cause of death worldwide.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Promotor: Prof.dr. J. Kuiper

In 2015, CML published over 70 papers, contributed to the United Nations conference on climate change in Paris, won awards and advised the Dutch government on the safe use of pesticides. CML awarded 11 PhDs and taught students from all over the world how to contribute to sustainability. We wish you…

Het Leiden Leadership Centre is lid van de Global Leadership Centres Roundtable (GLCR). De Global Leadership Centres Roundtable is het internationale netwerk van universitaire leiderschapscentra.

Promotor: G.J.B. van Ommen

Promotor: J.W. van Holten

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Congres/symposium

In samenwerking met Rijksmuseum Boerhaave, naar aanleiding van de tijdelijke tentoonstelling 'Dichter bij het zwarte gat', te zien t/m 5 januari 2025.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

In het najaar van 2021 deelden Cleveringa-hoogleraar Roméo Dallaire en werelddeskundigen hun gedachten over PTSS, kinderrechten, oorlogsmisdaden, humanitair recht en vredeshandhaving in een reeks gesprekken over leiderschap en morele dilemma's in tijden van conflict en crisis.

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Onze medewerkers en studenten maken deel uit van de taskforces van Una Europa. Deze taskforces vertalen de kernthema’s van Una Europa naar concrete acties.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Ons onderwijsaanbod is breed en divers. Hieronder vindt u alle informatie over de vakken die door de afdeling Bedrijfswetenschappen worden verzorgd. Als u op een vak klikt, wordt u doorgeleid naar de studiegids.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

Cardiovascular diseases are still a major concern for the global health.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

Leidse wetenschappers en bedrijven ontvangen 1,37 miljoen euro om technologie voor de Einsteintelescoop te ontwikkelen. Deze ondergrondse telescoop gaat zwaartekrachtgolven meten en moet dus extreem gevoelig zijn. Het consortium doet daarom onderzoek naar het dempen van trillingen bij temperaturen rond…

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Promotor: Prof.dr. L.J. Slikkerveer

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…