In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Anthropogenic change is reshaping ecological systems, raising concerns about increasing transmission of infectious diseases. Among these, mosquito-borne diseases may be particularly sensitive to environmental change, as their transmission depends on vector populations.

Dit project beoogt de ontwikkeling van geavanceerde data-analysemethoden voor monitoring en het vergroten van ons inzicht in de dynamiek van de biodiversiteit in natuurgebieden zoals de Oostvaardersplassen.

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

Over de hele wereld staan koraalriffen onder druk. Zarinah Waheed onderzocht de riffen in Maleisië en komt tot de conclusie dat de bescherming van koraalriffen beter kan. Promotie op 22 november.

Congres/symposium

Instituut Politieke Wetenschap

Ontdek de MSc The Politics of Artificial Intelligence aan Universiteit Leiden: analyseer wie AI ontwerpt, bestuurt en profiteert, terwijl je politicologische kern­theorieën inzet op regulering, ethiek en mondiale impact.

Dinsdag 11 februari bezocht de Europese toezichthouder voor gegevensbescherming, de heer Wojciech Wiewiórowski, eLaw - Centrum voor Recht en Digitale Technologie, om een ​lezing te geven over gezichtsherkenningssystemen en gegevensbescherming in Europa.

De European Cooperation in Science and Technology (COST) heeft een netwerksubsidie toegekend voor het project GoodBrother. Vanuit de Universiteit Leiden heeft Bart Custers, hoogleraar Law & Data Science en directeur van eLaw, Centrum voor Recht en Digitale Technologie, aan het voorstel meegeschreve…

Twee van eLaw's Advanced Masters-studenten, Dimitra Laskari en Vasilis Xynoglas, presenteerden hun onderzoek naar Metaverse en Personal Digital Twins op de Neurocognition and the Reproduction of Space-conferentie in Shanghai in China.

Het Dagelijks Bestuur van de sectie bestaat uit:

Dit programma is speciaal ontwikkeld om je te helpen met:

Metafysica en de grenzen van wetenschap

Binnen de opleiding Filosofie richt je je op verschillende deelgebieden binnen de westerse filosofie.

Wil je precies weten hoe het masterprogramma Encyclopedie en filosofie van het recht is opgebouwd en welke colleges je volgt?

Het Centre for Public Values & Ethics (CPVE) is een interdisciplinair academisch expertisecentrum met als doel het verrichten en verspreiden van wetenschappelijk onderzoek naar waardengeladen vraagstukken in de publieke sector. In het bijzonder wordt gekeken naar de ethiek van de publieke ambtsvervulling…

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Promotor: Prof.dr. M.K. Richardson

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Heart failure is a major health care problem with high mortality.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Songbirds as vocal learners learn their songs and song preference from social tutors⁠. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song⁠.

Consequences for sediment stability and seston trapping

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk