Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Op 11 november organiseerde de bacheloropleiding Molecular Science and Technology een corona-proof diploma-uitreiking met een bijzondere afstudeerder: de 18-jarige Ruard van Workum. Al van jongs af aan ontwikkelde Ruard een passie voor scheikunde. Hij begon op 15-jarige leeftijd met de opleiding Molecular…

This thesis is about the study of hydrocarbons via infrared spectroscopy.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Heterogeneous catalysis is essential to many industrial applications. These catalysts are often comprised of supported nanoparticles, which contain various different surface sites.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.

Promotie

Menselijke cellen beschermen hun eiwitten tegen ontvouwen en samenklonteren. Dat ontdekten biofysicus Alireza Mashaghi en zijn team na zeven jaar diepgaand onderzoek naar de vouwmechanismen van eiwitten. Met een nieuwe, baanbrekende methode slaagde het team erin om een afzonderlijk eiwit te vouwen en…

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Promotor: H.V.J. Linnartz

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

Promotie

Promotor: Prof.dr. E. F. van Dishoeck

Michel Orrit heeft een subsidie ontvangen uit het NWO-TTW Open Technologieprogramma. Hij gaat de kleine half miljoen euro gebruiken om individuele moleculen in beeld te brengen zonder fluorescentie te gebruiken.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

Studievoorlichting

Eiwitten in cellen visualiseren zonder invasieve technieken? Dat kan met behulp van fluorescentie. Michel Orrit, winnaar van de Spinozapremie 2017 én grondlegger van het vakgebied single molecule optics, legde op 18 januari aan de leden van het Natuurwetenschappelijk Gezelschap Leiden en andere geïnteresseerden…

Het is nog nooit gelukt om een enkel elektron te detecteren met zichtbaar licht via slechts één molecuul. Leids natuurkundige Michel Orrit en zijn onderzoeksgroep hebben nu een molecuul geïdentificeerd dat gevoelig genoeg is om een elektron te detecteren op een afstand van honderden nanometers. De resultaten…

In the first part of this thesis we study the geometry of folding patterns.

Promotor: T. Schmidt

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

Op 12 september heeft Michel Orrit zijn Spinozaprijs in ontvangst genomen uit handen van OCW staatssecretaris Sander Dekker in de Koninklijke Schouwburg in Den Haag. Met de prijs is een premie gemoeid van 2,5 miljoen euro, die vrij is te besteden aan wetenschappelijk onderzoek naar keuze, en het felbegeerde…

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…