Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Curved single crystals provide variable, but well-defined surface structures.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Vast, often populated, areas in dryland ecosystems face the dangers of desertification.

Promotor: Prof.dr. J.N. Kok

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

The ReCiPe methodology for Life Cycle Impact Assessment (LCIA).

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Technologies that help to enhance our educational environments can be found everywhere.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

Artful Mathematics: The Heritage of M. C. Escher

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.

SDN (Software-Defined Networking) represents a revolutionary approach to network architecture that enables the dynamic and flexible management of network resources through software-based control. This dissertation introduces the idea of SDN and its southbound protocol OpenFlow, then presents the formal…

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Promotores: J.N. Kok, H.J. Hoogeboom

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Verloren lading op zee moet worden beschouwd als milieuvervuiling en informatie hierover moet openbaar worden gemaakt, maar dat gaat niet altijd goed.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

To study how planetary systems come into existence we study much younger systems still in formation.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

Promotor: Prof.dr. G.J. Kroes

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Promotor: Prof.dr.ir. E. Deprettere

Possible improvements for the assessment of abiotic depletion in LCA.

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

Promotor: J.W.M. Frenken

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.

Promotor: K.J. Batenburg

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Promotor: W. Jiskoot, Co-promotor: H.A. Every