Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

An interdisciplinary collection of the best international scholarship on Muslim youth.

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Promotor: M.T.M. Koper, Co-promotors: A.I. Yanson, L.B.F. Juurlink

Did the Jochids leave their mark on the Grand Duchy, taking into account that the Lithuanian state was one of the main successor states of the Great Horde in the 16thCentury?

Het Skandapurāṇa Project, dat een internationaal consortium van wetenschappers verenigt, bestaat uit een team van onderzoekers die werkzaam zijn op verschillende gebieden van de geesteswetenschappen. We creëren een kritische editie van een fundamenteel werk uit de purāṇische literatuur en traceren zo…

Op 8 september kwamen de studenten van de master European Law bijeen in de Lorentzzaal voor de feestelijke opening van hun programma.

Op 30 oktober jl. bezochten de studenten van de advanced master International Children’s Rights het Internationaal Strafhof te Den Haag.

The Utrecht-based VIDI project Lettercraft in Early Medieval Europe, AD 481-751 is working on a new database of Merovingian epistolary communication. We are looking for enthusiastic (R)MA students who would like to join us this Fall as research apprentices for the first phase of data entry and analysis.…

Voor studenten die graag een intermediair zijn tussen wetenschappelijke experts, beleidsmakers en politici op het gebied van duurzaamheid, is het masterprogramma Governance of Sustainabiliy wellicht precies wat ze zoeken. De Universiteit Leiden is voornemens deze nieuwe masterstudie in Den Haag te beginnen…

Op 25 oktober 2017, bezochten de huidige studenten van de advanced master International Children’s Rights van de Universiteit Leiden justitiële jeugdinrichting ‘De Hunnerberg’ in Nijmegen.

Promotor: Prof.dr. H.S. Overkleeft

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Fundamental research in the ALgebra, Geometry And Number Theory

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

The project Multimedia Research and Documentation of African Oral Genres: Connecting Diasporas and Local Audiences (Director: D.Merolla) focuses on multimedia as technology that allows scholars to share documentation and scientific knowledge with the cultural owners of the collected oral genres.

Op 7 december 2021 verdedigde Georgina Kuipers het proefschrift 'Beschadigd vertrouwen'. Het promotieonderzoek is begeleid door prof.mr. W. den Ouden en prof.dr. M.A. van der Steen (EUR).

Tumoren gedragen zich als mini-orgaantjes, manipuleren hun omgeving en gebruiken lichaamseigen processen om te overleven en uit te zaaien. Door onderzoek van Erik Danen en zijn collega’s komen we steeds meer te weten over de complexe aard van tumorcellen. In het NRC vertellen de wetenschappers over…

Afgelopen maandag, 5 oktober, heeft prof. Tony Bovaird (Universiteit van Birmingham) een bezoek gebracht aan het Instituut Bestuurskunde. In het kader van het vak ‘Co-Production and Citizen Engagement’ (onderdeel van de Mastertrack ‘Public Management’) werd een mini-conferentie georganiseerd.

Strictly for Business is een competitie om IT-professionals van bedrijven en universiteiten met elkaar in contact te brengen. Teams van 4 of 5 studenten, 2 'Young IT professionals' uit deelnemende bedrijven én een docent van de opleiding als coach strijden tegen elkaar. Uit Leiden hebben twee teams…

Tijmen richtte zich op de ontwikkeling van een screening platform waarop prostaatkankercellen worden onderzocht in een driedimensionale celkweek. De 3D celkweken bieden een betere fysiologische omgeving om stoffen te testen dan de 2D omgeving. Het platform is geoptimaliseerd voor gebruik met 384-wells…

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