Van basisschoolleerlingen tot studenten van de universiteit: het Levend Lab is voor veel mensen een waardevolle onderwijsplek. Jaarlijks traint het Levend Lab tientallen studenten op mbo-, hbo- en universitair niveau. Daarnaast kregen ruim duizend scholieren les op locatie, en namen basisscholen meer…

This thesis aims to test in vitro pipelines to rapidly and cost-effectively identify molecular mechanisms that drive adverse outcomes in clinical use.

Promotie

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

Hoe kunnen we onze maatschappij zo inrichten dat de wereld leefbaar blijft voor onszelf en al het andere leven om ons heen? Aan dat vraagstuk werken Leidse wetenschappers samen vanuit allerlei disciplines, van biologie tot datawetenschap en van milieueconomie tot archeologie.

Door de komst van alternatieven kunnen we de komende decenia radicaal minderen met vlees, zuivel en andere dierlijke producten. Dit zou enorme hoeveelheden land vrijmaken om schone energie te produceren en koolstof uit te atmosfeer te halen. Milieuwetenschappers Laura Scherer en Oscar Rueda schrijven…

Handen uit de mouwen voor duurzaamheid! Dat doen medewerkers en studenten op verschillende manieren, thuis en op de universiteit.

Bij de bacheloropleiding Molecular Science & Technology aan de Universiteit Leiden ontwikkelen studenten een sterke theoretische basis in de scheikunde en doen ze kennis van de technologische toepassingen op. Daarnaast leren studenten een bijdrage te leveren aan vraagstukken op het gebied van duurzaamheid,…

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

De verduurzaming van de openbare ruimte op de campus krijgt veel aandacht in dit project. Het wordt een aangename, groene verblijfsplek waar je kunt ontspannen en koelte kunt vinden op warme dagen.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

FSW-gebouw, Wassenaarseweg 52, 2333 AK, Leiden

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Planets are formed in disks of gas and dust around young stars.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Democratie begint bij de gemeente. Daar ligt de bron van burgerschap, zeker in Nederland, zo schrijven Wim Voermans en Geerten Waling in het boek Gemeente in de genen, dat 20 februari verschijnt bij uitgeverij Prometheus.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

Microben, dat zijn toch ziekmakers? Moeten we daar niet vanaf? Nou, liever niet, weet microbioloog Ben Lugtenberg. Zonder microben gaan we namelijk dood. Na zijn eerste boek 'Zó leuk is microbiologie' is er nu 'Gezond met microben'. Voor dit boek heeft hij 35 expert gevraagd iets te schrijven over…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

Promotor: Prof.dr. B. van de Water

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: B. van de Water

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Promotor: Prof.dr. B. van de Water

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Promotor: E.F. Smets Co-promotor: J. Geml

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotor: B.van de Water, Co-promotor: L.S.Price

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…