Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

Promotores: J. Zaanen, A. Parnachev

Promotor: W.T. de Groot

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: J. Aarts

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Supervisor: P.J.J. Hooykaas

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

One of the most important correlation functions in physics, especially in cosmology, is the energy density, which describes how much energy is present at each point in spacetime due to matter fields. A key contribution to the energy density of the primordial universe comes from gravitational waves (GWs),…

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Plastics have become an integral part of modern society due to their versatility and durability.

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Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Promotores: G.A. Persoon, H.H. de Iongh

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

This dissertation presents new cryptographic protocols, which can be divided into two families.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Promotor: Prof.dr. D. Bouwmeester

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Op 16 december 2021 verdedigde Lisanne van Houten het proefschrift 'Flexing the Slot Regime'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof. L. Pierallini (Luiss University Of Rome).

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Promotor: Prof.dr. H.S. Overkleeft

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu