Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

Voor haar onderzoek haalde promovenda Liselore Tissen het ene na het andere wereldberoemde schilderij door een 3D-scanner. De reproducties die dat opleverde, waren niet van echt te onderscheiden. Wat betekent dat voor onze interpretatie van kunst?

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

De huidige en toekomstige quantumcomputers vormen dezelfde uitdaging als de laser in zijn begindagen. In theorie werd voorspeld dat de laser een bron van zeer speciaal, zeer krachtig licht zou zijn. Maar in die tijd waren er geen duidelijke toepassingen voor. Critici van het idee noemden het een probleem…

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Dit project gaat over het ontwikkelen van een simulatieplatform voor de verspreiding van mis- en desinformatie.

Humans share meaning through language. Over time, repeated interactions have shaped languages into forms that match our cognitive preferences, making them structured, expressive, easy to learn, and ultimately, meaningful.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

De activiteit van het brein verandert naarmate mensen ouder worden, wat kan leiden tot cognitieve achteruitgang. Door hersendata van muizen en mensen te meten en vergelijken, wil de onderzoeker begrijpen hoe tijdens het ouder worden de ruizigheid van ons brein verandert en keuzegedrag beïnvloedt.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotor: F.S. de Boer Co-promotor: P. T. de Gouw

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Over the past two centuries, socioeconomic development has improved material living standards but has also intensified environmental pressures, including climate change and biodiversity loss.

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Promotores: S.J. Edixhoven, F. Andreatta

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Every day, the intestines face an enormous challenge. They must absorb nutrients, medicines, and other substances we consume, while keeping harmful compounds out.

Global Environmental Extensions Multi-Regional Input-Output (EE-MRIO) analysis is often used to analyze how changes in global and national demand for products lead to socioeconomic and environmental impacts at the national level.

Promotores: Wim Jiskoot; Ferry Ossendorp

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Promotores: J. Jonkers, K.E. de Visser

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

Promotor: P.D. Grünwald

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

De gegevens van 41 miljoen sterrenstelsels brengen het kosmologisch standaardmodel toch niet aan het wankelen. Tot die, voor henzelf verrassende conclusie, komt een internationaal team van onderzoekers met daarbij Koen Kuijken, hoogleraar bij de Leidse Sterrewacht.

Leidse onderzoekers hebben een nieuw model ontwikkeld om immunotherapie tegen kanker te verbeteren. Met een 3D-printer creëren ze mini-tumoren in een omgeving die lijkt op menselijk weefsel. Ook ontwikkelden ze een manier om in real-time te volgen wat er tijdens tests in deze mini-tumoren gebeurt.

Promotor: Richard D. Gill

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

Vier Leidse studenten die de masterspecialisatie Science Based Business volgen, bedachten een concept om met een 3D Bioprinter menselijke huid te produceren. Slachtoffers van brandwonden zouden dankzij Skinprint minder operaties nodig hebben en er minder littekens aan over houden.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotor: T. Schmidt

Promotores: G.W. Canters, T.J. Aartsma