Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Technologies that help to enhance our educational environments can be found everywhere.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Promotor: J. Kuiper

This dissertation advances automated negotiation by developing agents that can learn and adapt across diverse negotiation settings through three increasingly sophisticated approaches: automated algorithm configuration, portfolio-based strategy selection, and end-to-end reinforcement learning with graph…

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

Promotores: T.H. Oosterkamp, N. de Jonge

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Optimally solving real-world expensive Black-Box Optimization (BBO) problems w.r.t. real-world constraints, such as wall-clock time and computational costs, is extremely difficult and tedious.

Onderstaand een overzicht van alle vakken die door de afdeling Economie worden verzorgd.

Vind jouw thuis bij LUC! Wij zijn gevestigd in het hart van Den Haag. Met ons eigen gebouw en internationale profiel biedt LUC een omgeving voor iedereen die op zoek is naar een interculturele ervaring en die een verantwoordelijke wereldburger wil worden.

De onderzoeksgroep Business, Technology & Public Policy van de afdeling Bedrijfswetenschappen van Universiteit leiden houdt zich bezig met het onderzoeken van de dynamische wisselwerking tussen ‘nieuwe’ technologieën en de verschillende belanghebbenden die hiermee interacteren, waaronder consumenten,…

Public Administration is a major refereed journal publishing articles on public administration, public policy and public management.

Een van de terugkerende discussiepunten binnen het onderzoeksprogramma Criminal Justice vormt de vraag welke gedragingen wel en niet onder het bereik van de strafwet zouden moeten vallen. Deze vraag wordt vanuit juridisch-dogmatische en sociaalwetenschappelijke invalshoek onderzocht.

Workshop

Workshop

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

How can we broaden youth participation in STEM Learning

Workshop

The global agri-food system plays a critical role in food security and environmental issues.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.

In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Promotores: J. Kok, M. Chaudron (Chalmers University)

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

ELS@Leiden onderzoek omvat een breed scala aan empirisch-juridische projecten die worden uitgevoerd op Leiden Law School, vanuit het perspectief van meerdere disciplines en methodes. Hier kan je de publicaties van onze (voormalige) lab members vinden sinds het begin van het Sector Plan.

The main topic of this PhD thesis is the Arakelov ray class group of a number field, an algebraic object that contains both the ideal class group structure and the unit group structure.