858 zoekresultaten voor “berg cell” in de Publieke website
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Targeting bacterial pathogens with next-generation glycoconjugate vaccines
This thesis investigates innovative and classical strategies in glycoconjugate vaccine development to address the growing threat of multidrug-resistant bacterial infections.
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Lipid nanoparticle technology for mRNA delivery: Bridging vaccine applications with fundamental insights into nano-bio interactions
Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.
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Herta MohrWitte Singel 27A, Leiden
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De universiteit en de oorlog
De Universiteit Leiden gedenkt haar slachtoffers van de oorlog en eert alle leden van de universitaire gemeenschap die in verzet kwamen tegen onrecht.
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Training en certificering
Een belangrijk aspect van het bevorderen en waarborgen van goede onderzoekspraktijken bij het Instituut van Psychologie is ervoor zorgen dat medewerkers worden gefaciliteerd en begeleid door het aanbieden van informatie en middelen voor training. Op deze pagina wordt een overzicht gegeven van alle verschillende…
- Colofon
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In naam van God
Paul Cliteur en Dirk Verhofstadt gaan op zoek naar de bronnen van het theoterrorisme.
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Kunstgebitten, machines en stof
Over onorthodoxe uitingen van wetenschap.
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Contact
Het secretariaat van het Instituut Publiekrecht is gehuisvest in het Kamerlingh Onnes Gebouw, kamer B1.11.
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T-cell gene therapy for low mutational burden cancer
Promotie
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Primary T-cell responses against SARS-CoV-2 in hematological patients
Promotie
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Exploring big data approaches in the context of early stage clinical
Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Microglial lipid metabolism: a delicate balance
Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Piecewise deterministic Markov processes: an analytic approach
Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Bioorthogonal tools to study fatty acid uptake in immune cells
The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.
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Max FernkornFaculteit der Wiskunde en Natuurwetenschappen
m.fernkorn@lacdr.leidenuniv.nl | 071 5272727
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Benjamin TakFaculteit der Wiskunde en Natuurwetenschappen
b.l.t.tak@lacdr.leidenuniv.nl | 071 5276228
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Rafaella BuzatuFaculteit der Wiskunde en Natuurwetenschappen
r.buzatu@lacdr.leidenuniv.nl | 071 5276227
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Christian SchröterFaculteit der Wiskunde en Natuurwetenschappen
c.schroter@lacdr.leidenuniv.nl | 071 5272727
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Andreea Iosif
Faculteit der Wiskunde en Natuurwetenschappen
c.a.iosif@lacdr.leidenuniv.nl | 071 5276302
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Eliane ZügerFaculteit der Wiskunde en Natuurwetenschappen
e.a.k.zuger@lacdr.leidenuniv.nl | 071 5276227
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Yubin GuoFaculteit der Wiskunde en Natuurwetenschappen
y.guo.11@lacdr.leidenuniv.nl | 071 5276227
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Micha DrukkerFaculteit der Wiskunde en Natuurwetenschappen
m.drukker@lacdr.leidenuniv.nl | 071 5276271
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Jingchao WuFaculteit der Wiskunde en Natuurwetenschappen
j.wu@lacdr.leidenuniv.nl | 071 5276227
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Joey ZuijderveltFaculteit der Wiskunde en Natuurwetenschappen
j.l.zuijdervelt@lacdr.leidenuniv.nl | 071 5276227
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Daan VlemmingsFaculteit der Wiskunde en Natuurwetenschappen
d.m.j.vlemmings@lacdr.leidenuniv.nl | 071 5276302
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Nina SchultenFaculteit der Wiskunde en Natuurwetenschappen
n.schulten@lacdr.leidenuniv.nl | 071 5272727
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Ruben de VriesFaculteit der Wiskunde en Natuurwetenschappen
r.j.de.vries@lacdr.leidenuniv.nl | 071 5276228
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Yuting WangFaculteit der Wiskunde en Natuurwetenschappen
y.t.wang@lacdr.leidenuniv.nl | 071 5272727
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Ferdinand TeichertFaculteit der Wiskunde en Natuurwetenschappen
f.m.a.teichert@lacdr.leidenuniv.nl | 071 5272727
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Cecile Herbermann -
Rafaël VosFaculteit der Wiskunde en Natuurwetenschappen
r.e.vos@lic.leidenuniv.nl | 071 5272727