Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Het proefschrift omschrijft de chemische synthese van fenolische glycolipiden van verschillende mycobacteriën met het doel om deze te kunnen gebruiken voor immunologisch onderzoek.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.

Promotor: Prof.dr. J.N. Kok

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Promotie

Promotores: A.H. Meijer, H.P. Spaink

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Josien de Klerk en Tennessee Miller onderzochten de interactie tussen de ziekte- en herstelervaringen van studenten en de academische werkcultuur in deze context.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Hoe gebruiken ziekteverwekkende mycobacteriën de vetten in onze cellen, en hoe kunnen we dat tegenhouden?

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Hoe helpen lipasen in Mycobacterium tuberculosis de bacterie te overleven, en kunnen we deze enzymen gebruiken als doelwit voor nieuwe antibiotica?

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Kunnen kleine moleculen het immuunsysteem herstellen en helpen tuberculose te bestrijden door autofagie te stimuleren?

Promotie

Leidse wetenschappers onderzoeken de wereld om ons heen en geven hun kennis door aan toekomstige generaties. Zij geven gezicht aan de universiteit, ieder met zijn of haar individuele expertise en persoonlijke fascinatie voor het eigen vakgebied.

Dit project onderzoekt hoe mensen taalvormen zoals vragen of beweringen kiezen in het dagelijks spraakgebruik.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Control of infectious diseases poses continuous challenges for human health.

By drawing on the personal experiences of contributors based in different institutions and countries, the articles in this special issue provide a fairly broad overview of ethics practices and concerns in different localities (though not globally, as we had originally hoped), showing, as one student…

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Deze bundel onderzoekt sociale betekenis vanuit het perspectief van actuele theorieën in de pragmatiek.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.