Promotor: J. Aarts

Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Supervisor: P.J.J. Hooykaas

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Promotor: Prof.dr. H.J.A. Rottgering

Promotor: Bas Edixhoven, Promotor: Qing Liu

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

In this thesis, we develop a novel technique called Optical Near-field Electron Microscopy (ONEM), which aims to combine the advantages of both optical and electron microscopy: the high resolution of electron microscopy and the low sample damage of optical microscopy.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Single-layer graphene (SLG) has attracted considerable interest as a proton exchange membrane for direct methanol fuel cells (DMFCs), owing to its atomic thickness, mechanical robustness, and unique proton permeability.

Promotor: T.H. Oosterkamp

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

Promotores: Wim Jiskoot; Ferry Ossendorp

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

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Within the field of astronomy, understanding how galaxies grow and evolve from the Big Bang to the present day is a challenging and complex question.

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Onderzoek naar de onderliggende principes van de menselijke taal.

Promotor: Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Univ. de Bordeaux)

Promotores: J.C. van Houwelingen, S.A. van de Geer

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

In this thesis,

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotor: Prof.dr. M. Danhof

Op 16 december 2021 verdedigde Lisanne van Houten het proefschrift 'Flexing the Slot Regime'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof. L. Pierallini (Luiss University Of Rome).

In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Including modelling as part of software development appears to have various benefits.

Dit gedeelte bevat een overzicht van onze alumni, het loopbaanperspectief naast het doctoraat en "Alumni in beeld", waar we enkele voorbeelden geven van de carrières van sommige van onze alumni na hun promotie.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin