This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

The endophytic microbiota is a community of various microorganisms that reside in plant tissue. These microbes are known to promote plant health and resilience, and their members do not simply exist side by side.

Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.

Hydrogen fuel cells are expected to be pivotal in the energetic transition towards renewable energy sources such as solar and wind power. However, their industrial scalability is severely hindered by the high cost and degradation rate of platinum catalysts, one of their key components. Addressing this…

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Lezing, Tuesday Talk

Promotie

Van zwarte gaten tot kunstmatige intelligentie en van medicijnonderzoek tot data science: welkom in de fascinerende wereld van de Faculteit der Wiskunde en Natuurwetenschappen. Geregeld geven onze onderzoekers, studenten en gasten publieke lezingen over hun werk. U bent van harte uitgenodigd.

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

In this dissertation, we work towards an experiment in which we aim to bring a micrometer sized magnet at the tip of a soft cantilever into a superposition.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

De Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) kiest haar leden uit een select gezelschap van vooraanstaande onderzoekers. Op 17 september installeert de KNAW 21 nieuwe leden, waaronder Leids natuurkundige Michel Orrit.

Een speciaal type microscoop jaagt momenteel een revolutie aan in de biologie: de cryo-elektronenmicroscoop. Twee van zulke giganten staan sinds 2011 op de Leidse Faculteit der Wiskunde en Natuurwetenschappen. Hoogleraar Ultrastructuurbiologie Ariane Briegel vertelt hierover in het NRC Handelsblad.

De Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) kiest haar leden uit een select gezelschap van vooraanstaande onderzoekers. Op 17 september installeert de KNAW 21 nieuwe leden, onder wie Leids natuurkundige Michel Orrit en chemicus Hermen Overkleeft.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

De maandelijkse dosis onderzoeksinspiratie van Leiden Science, van onze medewerkers, voor onze medewerkers en alle andere nieuwsgierigen.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Promotor: A. Kros

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Promotor: J. A. Bouwstra

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Traditional biochemical methods for studying organelles require cell disruption, preventing the real-time observation of dynamic intracellular processes.

Het logo van de Universiteit Leiden, met letters zo klein als een bacterie. Wetenschappers van het LUMC en het Instituut Biologie hebben het kleinste logo ooit van onze universiteit gemaakt. Een grapje met een serieuze ondertoon: met de nieuwe microscoop waarmee het logo is gemaakt, kunnen zij nog gedetailleerder…

Promotor: Prof.dr. M.A.G.J. Orrit

Binnen Quantum Leiden doen verschillende groepen onderzoek naar quantumnetwerken en quantumsensing.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Promotor: M.A.G.J. Orrit

Understanding how nature captures and transfers solar energy is essential both for elucidating biological photosynthesis and for guiding the design of artificial light-harvesting systems.