3,087 zoekresultaten voor “discovery of the year” in de Publieke website
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Targeting the adenosinergic system
Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).
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The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal
Op 16 december 2019 verdedigde Jan-Harm de Villiers zijn proefschrift 'The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal'. Het promotieonderzoek is begeleid door promotor prof.dr. P. Cliteur.
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Transboundary Crisis Management Capacities of the European Union
Dit project onderzoekt het coördinerend vermogen van de EU in ernstige crises.
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Implementation of the EU Preventive Restructuring Directive Part I
In 2019 hebben het Europees Parlement en de Raad de Richtlijn Preventieve Herstructurering (2019/1023) aangenomen, die voorziet in minimale harmonisatie van onder andere preventieve herstructureringskaders (preventive restructuring frameworks, 'PRF'). Dit boek biedt verdiepende analyses van de implementatie…
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Historical institutionalism and policy coordination: origins of the European semester
This paper explores whether multilateral surveillance and policy coordination under the ES was based on a path-changing or a path-dependent mechanism
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New dimensions of the cellular response to DNA damage
Promotie
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Thermostable Nanodiscs for the development of novel biopharmaceuticals
Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Knowledge discovery from patient forums: gaining novel medical insights from patient experiences
Patients share valuable advice and experiences with their peers in online patient discussion groups.
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The Role of the United Nations General Assembly in Advancing Accountability for Atrocity Crimes: Legal Powers and Effects
Op 20 oktober 2021 verdedigde Michael Ramsden het proefschrift 'The Role of the United Nations General Assembly in Advancing Accountability for Atrocity Crimes: Legal Powers and Effects'. Het promotieonderzoek is begeleid door promotor prof.dr. N.M. Blokker.
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The noise of the hunt: effects of noise on predator-prey relationships in a marine ecosystem
The effects of anthropogenic noise on interactions between predators and their prey are still little understood.
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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Diversity and Functional Potential of the Sorghum Root Microbiome to Control Striga hermonthica
Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Influence of the electrode-electrolyte interface on electrochemical CO2 reduction reaction and hydrogen evolution reaction
The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.
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Effects of the early social environment on song and preference learning in zebra finches
Songbirds as vocal learners learn their songs and song preference from social tutors. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song.
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Accurate modeling of the dynamics of dissociative chemisorption on metal surfaces
Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.
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Sneller nieuwe medicijnen vinden – zonder de beperkingen van grote DNA-barcodes
Onderzoekers in Leiden, onder leiding van Sebastian Pomplun, hebben een nieuwe methode ontwikkeld om honderdduizenden moleculen te screenen voor geneesmiddelenonderzoek — dit keer zonder DNA-tags, maar met massaspectrometrie. ‘We wilden geneesmiddelenonderzoek sneller en toegankelijker maken,’ zegt…
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Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
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Permanent change? the paths of change of the European security organizations
Betekenen recente ontwikkelingen in de Europese veiligheidsarchitectuur het einde van de multilaterale samenwerking, of juist het begin van een nieuw tijdperk?
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Guidance documents of the European Commission in the Dutch legal order
Op 11 februari 2020 verdedigde Clara van Dam haar proefschrift 'Guidance documents of the European Commission in the Dutch legal order'. Het promotieonderzoek is begeleid door promotoren prof.dr. W. den Ouden en prof.dr. J.E. van den Brink (UvA).
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Financial Market Regulation and Supervision in: The Law of the European Union
Matthias Haentjens, Jouke Tegelaar en Dorine Verheij schreven het hoofdstuk Financial Market Regulation and Supervision, dat recentelijk is gepubliceerd in het belangwekkende handboek The Law of the European Union (voorheen Kapteyn & VerLoren van Themaat).
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Spontaneous hospitalization in the immediate aftermath of the Manchester arena bombing
In dit artikel presenteren Andrea Bartolucci en Michele Magni een evidence-based onderzoek naar de spontane opname van slachtoffers en de verdeling van patiënten in de onmiddellijke nasleep van de Manchester Arena Bombing.
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The pervasive informality of the international cybersecurity regime: Geopolitics, non-state actors and diplomacy
De auteurs analyseren twee belangrijke factoren die informaliteit verdiepen, namelijk multipolaire geopolitiek en de opkomst van niet-statelijke actoren.
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A dyadic method to investigate voting behaviour in the council of the European Union
Dit artikel introduceert een nieuwe dyadische benadering om stemgedrag in de Raad van de Europese Unie te bestuderen.
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Building Assyrian Society: The Case of the Tell Sabi Abyad Dunnu
Promotie
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Vooruitkijken naar ‘The Next Ten Years’ bij LDE-jubileumbijeenkomst
De strategische alliantie Leiden-Delft-Erasmus Universities bestaat tien jaar in 2022. Tijdens de jubileumbijeenkomst ‘The Next Ten Years’ in de Faculty Club op 12 april keken de partners terug op wat er bereikt is en werd er vooruitgekeken naar de grote maatschappelijk uitdagingen van de komende tien…
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Knowledge of Medicinal, Aromatic and Cosmetic (MAC) Plants in the Utilisation of the Plural Medical System in Pirgos and Praitoria for Community
Promotor: Prof.dr. L.J. Slikkerveer
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink
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Ecology of the Ethiopian wolf (Canis simensis Rüppell 1835) in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of
Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.
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Layered loyalties: the Natuurkundige Commissie in the Netherlands Indies (1820-1850)
This dissertation, Layered Loyalties: The Natuurkundige Commissie in the Netherlands Indies (1820-1850), studies the Natuurkundige Commissie.
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An examination of the suitability of PADev as a method for effective participatory assessment of the development of higher education institutions
Promotie
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Measuring sustainability: an elaboration and application of the system of environmental-economic accounting for Indonesia
Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…
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Latin America and the UN
Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.
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A Tale of Two Mosuls, The resurrection of the Iraqi armed forces and the military defeat of ISIS
Een verhaal van Twee Mosuls, De wederopstand van de Irakese strijdkrachten en de militaire nederlaag van ISIS. In dit artikel, gepubliceerd in het Journal of Strategic Studies, bespreken de auteurs Maarten Broekhof, Martijn Kitzen en Frans Osinga de militaire aanpassing door de Iraakse strijdkrachten…
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The Local Impact of a Global Court: Assessing the Impact of the International Criminal Court in Situation Countries
Op 9 januari 2019 verdedigde Marieke Wierda haar proefschrift 'The Local Impact of a Global Court: Assessing the Impact of the International Criminal Court in Situation Countries'. Het promotieonderzoek is begeleid door promotoren prof. dr. C. Stahn en prof.dr. L.J. van den Herik.
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Show me the money: the magic of the marketing and finance interface to drive financial performance in hospitality operations
Promotie
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The Western Part of the East Indies: Colonial Worldmaking and Global Knowledges at the Early Modern Cape Colony
Lezing, Global Histories of Knowledge Seminar
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Lokal: indigenous medical knowledge and practice for integrated nursing of the elderly with cardiovascular disease in Sumedang, West Java: towards
The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.
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Adding fuel to the conflict : how gas reserves complicate the Cyprus question
In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.
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Neutrinos From the Milky Way
Promotor: Prof.dr. M. de Jong
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Boeklancering 'The United Nations Convention on the Rights of the Child’
Het boek 'The United Nations Convention on the Rights of the Child' is het resultaat van internationale wetenschappelijke congres - '25 Years CRC' – dat plaatsvond in november 2014 in Leiden ter gelegenheid van de 25e verjaardag van het VN-Kinderrechtenverdrag.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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Dit was het Leiden Asia Year
Het jaar 2017 was het Leiden Asia Year. Leiden heeft al eeuwenlang banden met en kennis over het continent, en het afgelopen jaar werden daar de spotlights op gezet.
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Symposium: The digital reconstruction of the crucifixion of the Lindau master
On 8 July, the symposium 'The digital reconstruction of the crucifixion of the Lindau master (ca. 1425)' will take place at the auditorium of Museum Catharijnecovent, from where it will also be broadcasted online.
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Cædmon, Cynewulf and the Continent: The Search for Anglo-Saxon Christianity in 19th-century Europe
Sinds de 16e eeuw hebben religieuze overwegingen de studie van het Oudengels en zijn sprekers gemotiveerd. In de 19e eeuw wendden geleerden zich vooral tot de studie van de Oudengelse literatuur om sporen te vinden van voorchristelijke, 'Germaanse' religie, zoals besproken in Eric G. Stanley's baanbrekende…