In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

Het ministerie van Veiligheid en Justitie heeft in haar magazine Nationale Veiligheid en Crisisbeheersing uitgebreid aandacht besteed aan de ISGA conferentie 'Who determines the security (research) agenda?'. Leidse onderzoekers presenteren hun onderzoek op belangrijke thema’s zoals de nationale veiligheidsagenda,…

Al is Islamitische Staat grotendeels verslagen, de jihadscene in Nederland is voorlopig nog springlevend. Dat zei hoogleraar Edwin Bakker (Terrorisme en contraterrorisme) onlangs in een interview in het Algemeen Dagblad.

Security is key to survival for any living organism: life is full of perils and threats, both physically, environmentally, and societally. Security challenges such as terrorism, natural disasters, and cybercrime rank among the most pressing issues of our time, affecting the security and safety of millions…

Hoe de kans op recidive van extremistische gedetineerden kan worden geminimaliseerd.

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

De BioMedical Metabolomics Facility Leiden (BMFL) biedt een zeer gestructureerde omgeving voor geavanceerd metobolomicsonderzoek. BMFL is gebaseerd op volledig gevalideerde, moderne platforms die gezamenlijk het gehele menselijke metabolisme beslaan.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

This thesis investigates how non-genetic factors, such as inflammation and concomitant medication, impact hepatic drug metabolism and subsequent drug metabolizing phenotype predictions.

Promotie

In 'Barometer van de dreiging: Tien jaar Dreigingsbeeld Terrorisme Nederland 2005-2015' analyseren Bakker & de Roy van Zuijdewijn de ontwikkeling van DTN en diens positie in het Nederlandse terrorismebeeld door de jaren heen. Bakker & de Roy schreven dit essay in opdracht van de Nationaal Coördinator…

In dit vierde rapport worden ontwikkelingen besproken ten aanzien van het beleid met betrekking tot personen die terugkeren uit jihadistische strijdgebieden, zogeheten ‘terugkeerders’, voor de periode januari 2017 tot medio december 2018.

In dit artikel wordt de herkomst van de term narcoterrorisme onderzocht en gekeken in welke mate deze past bij de situatie in Nederland.

De Verdieping Bewaken en Beveiligen brengt verdieping aan op actuele gebeurtenissen en ontwikkelingen gerelateerd aan het stelsel Bewaken en Beveiligen.

Het Institute of Security and Global Affairs (ISGA) is een wetenschappelijk instituut, gespecialiseerd in veiligheidsvraagstukken. Het ISGA is ingebed in de Faculteit Governance and Global Affairs van de Universiteit Leiden.

De Verdieping Bewaken en Beveiligen brengt verdieping aan op actuele gebeurtenissen en ontwikkelingen gerelateerd aan het stelsel Bewaken en Beveiligen.

Om te werken aan grote maatschappelijke uitdagingen is onderzoek nodig die over de grenzen van traditionele disciplines heen te kijken. Wat ons betreft begint dat al bij het onderwijs. Door studenten bloot te stellen aan mensen van andere wetenschappelijke werelden leren ze omgaan met andere denkbeelden…

Je kiest voor de studie Bio-Farmaceutische Wetenschappen wanneer je sterk geïnteresseerd bent in de ontwikkeling van en het onderzoek naar de werking van geneesmiddelen.

In this dissertation (titled: Exploring the Synergies between Transfer in Reinforcement Learning and Procedural Content Generation) we explore how the two research fields named in the title, namely Transfer in Reinforcement Learning (TRL) and Procedural Content Generation (PCG) can synergize togethe…

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Promotores:Th.J.C. van Berkel, M. van Eck

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

Cardiovascular diseases are still a major concern for the global health.

During the course of drug discovery translational steps are made.

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

Promotor: A.P.IJzerman Co-promotor: A. Bender

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Promotor: W. Jiskoot, Co-promotor: A. Kros

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…