Het ProMiSe project heeft als doel om de ontwikkeling van kinderen met het Coffin-Siris syndroom en FOXP1 syndroom te onderzoeken. Deze kennis is belangrijk om ouders en zorgprofessionals beter te kunnen informeren en hen te ondersteunen bij de opvoeding.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Het onderzoek van de sectie Cognitieve Psychologie is onder te verdelen in twee domeinen.

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

When you have decided to participate in a Summer School of Leiden University, there are some matters you need to know before arrival. Please take a few minutes to read through the information here to find out what you can do from your side to smooth the process.

Lorenza Colzato wil onderzoeken of het gebruik van probiotica en tryptofaan de sociaal-cognitieve achteruitgang die optreedt bij het ouder worden, kan vertragen. Daarvoor ontvangt Colzato samen met haar collega's in Duitsland en Spanje een JPI 'A Healthy Diet for A Healthy Life' Joint Transnational…

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotor: Prof.dr. T. Schmidt

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Promotor: A.W. van der Vaart

Heart failure is a major health care problem with high mortality.

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Promotor: Prof.dr. G.P. van Wezel

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

Promotor: Prof.dr. J. den Hertog

Promotor: Prof.dr. E. F. van Dishoeck

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

This thesis covers various applications of topology in condensed matter physics and quantum information.

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This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Promotor: M.A.G.J. Orrit

Binnen het brede netwerk van de Universiteit Leiden neemt het instituut deel aan onderzoek binnen de volgende profileringsgebieden:

Kijk mee en praat mee over de wetenschap van het verleden tijdens wekelijkse Let’s Plays van populaire games en vodcasts op het livestreamplatform Twitch.

Archeoloog Victor Klinkenberg onderzocht een oude Assyrische nederzetting in Syrië, dichtbij IS-bolwerk Raqqa. ‘Al met al speelde het sociale leven een veel grotere rol dan het militaire.’ Promotie op 27 oktober.

De ziekte van Parkinson is een neurodegeneratieve aandoening die niet alleen wordt gekenmerkt door motorische symptomen, maar vaak ook gepaard gaat met cognitieve problemen. In deze pilotstudie zal worden onderzocht in hoeverre digitale thuistesten een haalbare en effectieve aanvulling kunnen zijn op…

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

This course explains the functions of each international court and tribunal in The Hague. On the basis of cases and interviews with judges and lawyers, this course explores the role of these courts and tribunals and their potential to contribute to global justice.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot