3,087 zoekresultaten voor “discovery of the year” in de Publieke website
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Twee Leidse finalisten Academische Jaarprijs op Discovery Festival
Universiteit Leiden is op 28 september met twee projecten aanwezig bij het Discovery Festival, een nachtfestival dat draait om de kick die je krijgt als je nieuwe dingen ontdekt. Antibiotica Gezocht! laat de festivalgangers meewerken in het tijdelijke laboratorium en iSPEX: ‘Meet fijnstof met je smartphone’…
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Chasing cosmic tau neutrinos in the abyss
In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.
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Expanding the chemical space of antibiotics produced by Paenibacillus and Streptomyces
Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…
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Leidse Sterrewacht neemt deel aan International Year of Light 2015
De Leidse Sterrewacht gaat deelnemen aan de activiteiten van het International Year of Light (IYL). Het jaar 2015 is door de Verenigde Naties uitgeroepen tot het International Year of Light and Light-based Technologies. IYL 2015 zal aan de wereld laten zien hoe belangrijk licht en optische technologie…
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abilities in children with sex chromosome trisomy (XXY, XXX, XYY) aged 1–6 years
Een goede taalontwikkeling is van belang voor de cognitieve en sociale ontwikkeling, om te kunnen communiceren en om te kunnen leren. Als de taalontwikkeling niet verloopt zoals verwacht, kan dit allerlei consequenties hebben. Kinderen met een extra X of Y chromosoom hebben een verhoogd risico op problemen…
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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CfP: Annual Conference of the International Society for the Study of Medieval Theology
On June 26-28, 2024, the Annual Conference of the International Society for the Study of Medieval Theology will take place. The theme this year is "The End: Finiteness, Death and Completion in Medieval Theology". Deadline for paper proposals: 20 December 2023.
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Leiden Law students are looking forward to the lawyer of the future
As Leiden Law students, we are now in the digital age, 'where we believe law and technology should go together.' After all, for us, it is important to look beyond trodden paths of established legal knowledge. The books on law and case law surely will not be sufficient for the lawyer of the future. That…
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Discovery of selective diacylglycerol lipase β inhibitors
Promotie
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Five years after Covid‐19: What have we learned (and forgotten)?
Dit artikel blikt vijf jaar na dato terug op de lessen van de COVID-19-pandemie. De crisis legde kwetsbaarheden bloot in zorgsystemen, bestuur en sociale samenhang.
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Solving the Gravitational N-body Problem with Machine Learning
In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.
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Visual Revolutions in the Middle East
Special Issue in: Visual Anthropology, Volume 29, Issue 3, 2016
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The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement
Op 26 juni 2019 verdedigde Lisa Louwerse haar proefschrift 'The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement'. Het promotieonderzoek is begeleid door promotor prof. mr. C.A.P. Hillion.
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Deep Hanging Out in the Age of the Digital; Contemporary Ways of Doing Online and Offline Ethnography
A brief review essay on some of the work that has been recently published in the emergent field of digital ethnography.
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Combining classic and novel tools in the study of Historical Collections of Chinese Materia Medica in the Netherlands
Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…
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Systematics and biogeography of the rattan Calamus javensis complex (Arecaceae, Calamoideae) in Malesia
Calamus javensis is polymorphic. Morphometry and molecular approach resulted in all names used in the complex are regarded as synonyms of C. javensis except C. tenompokensis, which is retained as a distinct species. One variety is here recognized, C. javensis var. polyphyllus (including C. acuminatu…
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Open government and public trust: a new revaluation of the citizen perspective
Hoe beïnvloedt open overheid het publiek vertrouwen?
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Patient-derived models of breast cancer: a breakthrough story of the duct
To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…
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Validity in teacher assessment. An exploration of the judgement processes of assessors
In dit proefschrift staat validiteit in de beoordeling van docentcompetenties centraal.
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Van Ham, Thomassen, Aarts & Andeweg (eds), Myth and Reality of the Legitimacy Crisis
Beleeft de democratie daadwerkelijk een legitimiteitscrisis? De auteurs toetsen de stelling dat gevestigde democratieën aan legitimiteit inboeten. Voorts bekijken zij in hoeverre bestaande theorieën de legitimiteitscrisis zien en verklaren. Ook onderzoeken zij nieuwe mogelijkheden voor het bestuderen…
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Antiquities of the rainforest: evolution of mycoheterotrophic angiosperms growing on Glomeromycota
Promotor: Prof.dr. E.F. Smets
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Preclinical Insights into Early Psychopharmacology Trials: Application of the IB-Derisk Analyser Tool
Promotie
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Towards Implementation of the Tumour-Stroma Ratio in Colorectal Cancer
Promotie
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Erik Danen benoemd tot hoogleraar Cancer drug target discovery
Met ingang van 1 april 2018 is Erik Danen benoemd tot hoogleraar Cancer drug target discovery bij het Leiden Academic Centre for Drug Research (LACDR). Zijn vakgebied is celbiologie van kanker, waarin hij zich richt op de achterliggende mechanismen bij uitzaaiingen en resistentie voor behandelingen.
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Star formation and aging at cosmic noon: the spectral evolution of galaxies from z=2
Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)
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Star-Forming Galaxies at the Cosmic Dawn
Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens
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The impact of sustainable forest management on plant and bird diversity in East Kalimantan, Indonesia
Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters
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NMR structural studies of protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal
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Sugoi! Leiden Asia Year van start op dies
Een jaar lang staat Leiden in het teken van Azië met talloze Aziatische evenementen, conferenties, tentoonstellingen en concerten. Aanleiding is de nieuwe Asian Library van de Universiteit Leiden. Kom lezen, kijken, luisteren, proeven of dansen zoals ze dat doen in Bollywood of Indonesië.
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Digging for data: the rise and fall of a Miocene mammal biodiversity hotspot in the Vallès-Penedès (Catalonia, Spain)
The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.
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The resilience of tropical intertidal seagrass meadows, grazed by dugongs, and the impact of anthropogenic stressors
Seagrass is a marine flowering plant with special adaptations to coastal and marine environments, playing a crucial role in providing a wide range of ecosystem services.
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Course: Introduction to the Archaeology of the Book
The Summer School History of the Book, organized by the Allard Pierson Museum, introduces a new course in English: Introduction to the Archaeology of the Book, taught by Prof. Malcolm Walsby (2-6 September 2024).
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Corruption & Integrity in the Netherlands (1945 - present)
Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…
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The Future of Paleography, Paleography of the Future
The first congress of the UU Paleohub, 'The Future of Paleography, Paleography of the Future'. 10 april 2025
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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Human-wildlife Interactions in the Western Terai of Nepal
Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.
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Summer School on the History of the Book
Van 21 augustus tot en met 8 september zijn de workshops en cursus van de jaarlijkse Summer School on the History of the Book van het Allard Pierson en de vakgroep Boekwetenschap. Drie weken lang is er elke werkdag een cursus, workshop of lezing over thema’s die te maken hebben met de geschiedenis van…
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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2017: Leiden Asia Year. Kom met ideeën!
Het Leiden Asia Year komt eraan. 2017 staat bij de universiteit en in de stad helemaal in het teken van Azië . Heb je ideeën om het programma nog mooier te maken? Meld ze bij de universiteit!
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The effects of burying beetle social behaviours on interspecific interactions
This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.
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Furthering the fight against impunity in Latin America: the contributions of the Inter-American Court of Human Rights to domestic accountability
Op 3 december 2019 verdedigde Hanna Bosdriesz haar proefschrift 'Furthering the fight against impunity in Latin America: the contributions of the Inter-American Court of Human Rights to domestic accountability processes'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik…
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The Role of Efficient Causation in Aristotle’s Philosophy: Ensuring the Continuity and Coherence of the Cosmos within a Teleological Framework
Promotie
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LED3 & LUCID Drug Discovery Meeting
Congres/symposium
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.