Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotor: W. Jiskoot, Co-promotor: A. Kros

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Ontdek het studieprogramma van de éénjarige MSc Nederlandse Politiek aan Universiteit Leiden: kernvak, keuzevakken, onderzoeksvaardigheden, scriptiebegeleiding en stageoptie.

Afgestudeerden van de bachelor Security Studies aan de Universiteit Leiden hebben toegang tot diverse masterprogramma's en uitstekende carrièrekansen. Ontwikkel je als beveiligingsstrateeg en vergroot je kansen op een succesvolle carrière in zowel de publieke als private sector.

Kunst en vrije tijd, Kunst en vrije tijd

Een overzicht van awards en prijzen die in 2021 zijn toegekend aan onze medewerkers en studenten, maar ook bijzondere benoemingen aan de Universiteit Leiden en andere instellingen.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

Regeneration is the ability of an organism to restore damaged or lost tissue with a functional replacement, and without scarring. Many lizards can regenerate their tails.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.

Promotor: Prof.dr. M. de Jong

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotores: H.A. Udo De Haes, P.M. Brakefield

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

This research delves into a region of space known as the interstellar medium (ISM), which is essentially the area between the stars filled with gas and dust.

The applications of studying the early development of insects range from agriculture to material science.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Promotores: T.H. Oosterkamp, N. de Jonge

De onderzoeksgroep Governance of Crises bestudeert fenomenen, dynamieken en actoren die te maken hebben met crisisgovernance. Het Crisis Research Center (CRC) van de Universiteit Leiden maakt deel uit van deze onderzoeksgroep.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotores: S.F. Portegies Zwart, E. M. Rossi

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

In this thesis, rational points on K3 surfaces are studied. In the first part of Chapter 1 the Brauer group and the the Brauer-Manin obstruction are introduced.

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

De complotten over corona ontwikkelen zich langs vertrouwde lijnen. Maar opmerkelijk is dat ze niet alleen floreren in de marge, maar in sommige landen in de hoogste regionen opduiken. Jelle van Buuren, universitair docent aan de Universiteit Leiden, onderzocht complottheorieën rondom het coronaviru…

De ‘Verdieping Bewaken en Beveiligen’ brengt verdieping aan op actuele gebeurtenissen en ontwikkelingen gerelateerd aan het stelsel Bewaken en Beveiligen.