Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

Promotor: W.T. de Groot

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Studievoorlichting

Forming at the nodes of the Cosmic Web and growing hierarchically via mass accretion, galaxy clusters are the largest virialized halos in our universe, composed of dark matter (DM; ≥85%), ionized hot plasma in the intracluster medium (ICM; ≥10-15%), and galaxies (≥1-5%).

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Promotie

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Op 1 juni 2022 verdedigde Tom Herrenberg het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. P.B. Cliteur en prof.dr. B.R. Rijpkema.

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Promotor: Prof.dr. S. Haring

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Supply risks are not new. But the aggravation of power conflicts on the international stage coupled with global shifts towards energy transition and digitalization has triggered the next supply risk research era.

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

Promotor: Prof.dr. A.G.G.M. Tielens

Sinds de 16e eeuw hebben religieuze overwegingen de studie van het Oudengels en zijn sprekers gemotiveerd. In de 19e eeuw wendden geleerden zich vooral tot de studie van de Oudengelse literatuur om sporen te vinden van voorchristelijke, 'Germaanse' religie, zoals besproken in Eric G. Stanley's baanbrekende…

Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

The first direct detection of gravitational waves opened the possibility of mapping the Universe via this new and independent messenger.

Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Onderzoeksastronomen, wetenschappers, beleidsmakers, journalisten en wetenschapscommunicators en -educatoren komen vier dagen bij elkaar om tijdens een symposium over verschillende thema’s uit de astronomie te discussiëren. En iedereen die zich wil mengen in de discussie is de eerste avond van het symposium…

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Sager, Overeem en anderen onderzoeken of het gedeelde idee van een ‘rijksambtenaar’ in Europa bestaat.

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

The combination of data science and sports is a hot topic. In a talk during the opening of the Academic Year at the Faculty of Science, Professor Joost Kok explained what data analytics can teach us about sports.

Eva Michaels & Monika Sus onderzoeken Europese Strategische Autonomie als reactie van de EU op de fragmentatie van de Liberale Internationale Orde.

Op 10 november 2021 verdedigde Carmel van Niekerk-Jacobs het proefschrift 'Realising the right to reproduce with assistance in South Africa'. Het promotieonderzoek is begeleid door prof.dr. J.J. Sloth-Nielsen en prof.dr. T. Liefaard.

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…