Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

The project Multimedia Research and Documentation of African Oral Genres: Connecting Diasporas and Local Audiences (Director: D.Merolla) focuses on multimedia as technology that allows scholars to share documentation and scientific knowledge with the cultural owners of the collected oral genres.

Promotores: Wim Jiskoot; Ferry Ossendorp

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The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotor: Prof.dr. B. van de Water

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

An interdisciplinary collection of the best international scholarship on Muslim youth.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Nieuw handboek geschiedfilosofie van Herman Paul in de reeks 'Wetenschapsfilosofie in context'.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

De Universiteit Leiden heeft onderzoeksinstituten gevestigd in Leiden en Den Haag.

Zoeken naar best practices voor en nieuwe inzichten in professionele training en ontwikkeling van docenten.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Biopinters waarmee wetenschappers complexe weefsels en organen kunnen namaken. Het klinkt als science-fiction, maar niet voor Alireza Mashaghi en zijn collega’s van het Leiden Academic Centre for Drug Reserch. Hun lab is onlangs uitgerust met twee ultramoderne bioprinters: BioX en LumenX+. Mashaghi:…

Vanuit een fraai verlicht Academiegebouw hield Maxim Februari op 11 december de 49e Huizingalezing. In de zaal waren slechts 30 mensen aanwezig, online keken er maar liefst 550 mensen naar de lezing en het aansluitende interview met Maxim Februari door studenten Maria en Friso. Kijk de lezing hier terug,…

Het doel van het RESOCIAL project is om zich te verdiepen in menselijke kwetsbaarheiden binnen sociale media en de metaverse. Een belangrijk aandachtspunt van het project is de ontwikkeling van een omvattend raamwerk voor het beoordelen van de impact van deze platformen op fundamentele rechten.

Van oudsher zoeken gezondheidswerkers naar manieren om ziektes onder kwetsbare bevolkingsgroepen te bestrijden. Inmiddels blijkt hoe dit onderzoek ook welvarender landen ten goede komt. Afrikaanse worminfecties en innovatieve thermometers leren Leidse onderzoekers hoe je welvaartsziekten kan bestrijden…

Internationale gerechtshoven (ICT’s) zijn financieel afhankelijk van de landen die ze oprichten, wat een risico vormt voor ongewenste staatsinvloed op de juridische rechtsgang. In haar proefschrift onderzoekt Maria Manolescu mechanismen die de rechterlijke onafhankelijkheid waarborgen, zodat rechters…

Drie onderzoekers van eLaw – Centrum voor Recht en Digitale Technologie – waren significant betrokken bij de ACM-conferentie over Eerlijkheid, Verantwoording en Transparantie (FAccT), die van 25 tot 27 juni in Athene werd gehouden. Francien Dechesne, Gianclaudio Malgieri en Maria-Lucia Rebrean waren…

In de aanloop naar Kerstmis zendt NPO 2 een derde documentairereeks uit over Jezus van Nazareth.

Het Gorlaeus Gebouw wordt in drie fasen gerealiseerd. Het nieuwe gebouw is medio 2028 helemaal gereed.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Persoonlijke briefjes uit middeleeuws Rusland? We kennen wel veel officiële en kerkelijke documenten, maar de vondsten van stukjes beschreven berkenbast uit Novgorod geven op een unieke wijze inzicht in hoe 'gewone' mensen dagelijks met elkaar communiceerden.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: B. van de Water

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.