Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

Promotor: Prof.dr. M. Ubbink

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

Sustainable energy from wind and solar is most readily available near the sea.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Promotor: Prof.dr. H.J.A. Rottgering

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Supervisor: P.J.J. Hooykaas

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Onder vindt u de wetenschappelijke publicaties van het Navigatie Lab Leiden

Positieve herinneringen ophalen kan helpen om je beter te voelen over jezelf. Daarmee wil Charlotte van Schie mensen met een borderline persoonlijkheidsstoornis sterker maken. Ze publiceert over haar onderzoek in Human Brain Mapping en geeft op de LIBC-publieksdag 11 oktober de flashtalk: 'Gekleurde…

Promotie

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: F.J. van Lunteren, E. Jorin

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

This PhD-thesis analyses the relationship between the parties’ choices in the CPB Netherlands Bureau for Economic Policy Analysis’ assessments of the election manifestos and coalition agreements over the period 1986-2017, and tries to explain this relationship.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

The zoo of detected exoplanets reveals both the uniqueness of our own Solar System and the complexity of planetary system formation, sparking fundamental questions about how planetary systems form and evolve.

In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

De Faculteit Geesteswetenschappen biedt plaats aan een verscheidenheid aan gerenommeerde Nederlandse en internationale academici met expertise in een groot aantal vakgebieden die samen bijna alle continenten en periodes beslaan.

ACPA biedt keuzevakken in kunst, muziek en film. Als student van de Universiteit Leiden maar ook als student van de Hogeschool der Kunsten Den Haag(Koninklijk Conservatorium en Koninklijke Academie van Beeldende Kunsten Den Haag) kun je via ACPA deze keuzevakken volgen.

De bachelorpleiding Psychologie in Leiden bestrijkt de volle breedte van de psychologie. Onze bachelorstudenten krijgen volop mogelijkheden voor specialisatie. In de masteropleiding bereiden studenten zich voor op een loopbaan als 'scientist - practitioner'. In de eenjarige masteropleiding ligt de nadruk…

Het onderzoek van de sectie Cognitieve Psychologie is onder te verdelen in twee domeinen.

NASA’s telescoop SOFIA geeft een nieuw kijkje in de chemie nabij jonge sterren: de geboorteplaats van nieuwe planeten. De Leidse promovendus Andrew Barr schrijft erover in de Astrophysical Journal. Hij en zijn collega’s vonden enorme hoeveelheden water en organische moleculen in de wervelende, schijfvormige…

Het Instituut Psychologie streeft nationaal en internationaal naar een prominente rol in onderwijs en onderzoek.

Promotie

Religion, Philosophy, and the Pre-modern World

In this thesis we use state-of-the-art observations and simulations to provide the best constraints to date on the HVS ejection rate and constraints on the stellar content and dynamics at the GC, including the progenitor binary populations and their star formation history.