Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Promotor: M.A.G.J. Orrit

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Studievoorlichting

Video games have emerged as one of the most interesting media of the turn of the century. The peculiar characteristic of video games is the biunivocal interaction between the computer and the human player.

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

This PhD-thesis analyses the relationship between the parties’ choices in the CPB Netherlands Bureau for Economic Policy Analysis’ assessments of the election manifestos and coalition agreements over the period 1986-2017, and tries to explain this relationship.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Gendergerelateerd geweld is een urgent maatschappelijk probleem dat jaarlijks het leven van tienduizenden mensen in Nederland ingrijpend raakt.

Voor veiliger digitaal verkeer is aanscherping van de wettelijke kaders noodzakelijk. Bovendien moeten de grootste cyberdreigingen geïdentificeerd worden.

Jaarlijks verliezen zo’n veertig vrouwen in Nederland hun leven, veelal door een (ex-)partner of familielid. Rechters, advocaten en ervaringsdeskundigen wenden zich rechtstreeks tot hoogleraar Marieke Liem. Een signaal, vindt Liem: ‘Hoog tijd voor meer kennis en een gezamenlijke aanpak.’

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

The ultimate aim of this project (initiated by the European Law Institute) is to design a framework that will enable the further development of coherent and functional rules for business rescue in Europe.

Hoe kunnen we op een interdisciplinaire wijze de classificatie van migranten en mensen met een beperking bestuderen en onderzoekers van deze velden samenbrengen om raakvlakken met elkaar te vinden?

Werken aan ICT bij een topuniversiteit? Met uitstekende carrièremogelijkheden? Ontdek het werken bij het ICT Shared Service Centre van de Universiteit Leiden.

Het Center for Interdisciplinary Placebo Studies Leiden (IPS) streeft naar een beter begrip van placebo- en nocebo-effecten, hun onderliggende mechanismen en hun mogelijke toepassingen in de klinische praktijk. IPS bestaat uit een groep interdisciplinaire onderzoekers die werken aan de Universiteit…

A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

Workshop

How can we broaden youth participation in STEM Learning

Seagrass is a marine flowering plant with special adaptations to coastal and marine environments, playing a crucial role in providing a wide range of ecosystem services.

Op donderdag 2 september jl. trad Maaike Lycklama à Nijeholt op als keynote spreker op het behavioral risk congres in Utrecht. Zij deed dit samen met Desiree Meurs, onderzoeker bij Hogeschool Rotterdam. Het congres vond plaats in Pathé in Leidsche Rijn. Het thema van het congres was “innovatief toezicht…

Het ICLON doet onderzoek naar het basis- en voortgezet onderwijs.

The Sundanese people, the largest ethnic group in West Java, have been using traditional medicine for a long time. Known as ubar kampung, Sundanese indigenous knowledge, beliefs and practices of traditional medicine are based on local people’s knowledge and use of Medicinal, Aromatic, and Cosmetic (MAC)…

Onderwijsonderzoek

This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

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De organisatie voor Economische Samenwerking en Ontwikkeling (OESO) heeft in samenwerking met het Inter-American Center of Tax Administrations (CIAT) op 27 november 2023 een wereldwijde online Tax Morale Workshop georganiseerd, waar Esther Huiskers-Stoop van de Universiteit Leiden en Diego Quiñones…

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…