Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

An interdisciplinary collection of the best international scholarship on Muslim youth.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Promotor: Prof.dr. B. van de Water

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

De Universiteit Leiden heeft onderzoeksinstituten gevestigd in Leiden en Den Haag.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Zoeken naar best practices voor en nieuwe inzichten in professionele training en ontwikkeling van docenten.

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

Studievoorlichting

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Het project 'De Top 40 van de Gouden Eeuw' heeft als doel om de liedcultuur van deze periode beter in beeld te brengen. Universitair docent Olga van Marion is bij dit project betrokken. Om deze Top 40 op te kunnen nemen en uit te kunnen brengen, is er een crowdfundingsactie gestart.

Twee studenten van de bacheloropleiding Nederlandse taal en cultuur, Ditmar Bakker en Anne Grisnich, ontvingen respectievelijk de eerste en tweede prijs van de Vertaalwedstrijd 'Het Leven is Droom'. De prijsuitreiking vond plaats op 31 oktober tijdens de Studiedag over Het Leven is Droom.

We maken ons allemaal zorgen over hoe we door anderen worden gezien. Het nog te verschijnen boek Vertrouw mij! - onder redactie van Jaap de Jong, Olga van Marion en Adriaan Rademaker - laat zien hoe je je publiek verleid om naar je te luisteren. Het imago is daarin vaak de doorslaggevende factor.

De identiteiten van Leiden. Dat is het onderwerp van een symposium op 3 november in de Burgerzaal van het Leidse stadhuis. Onderzoekers van de Universiteit Leiden en aanverwanten doken in de geschiedenis maar proberen ook een link met het nu te leggen.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Als alumnus van de Universiteit Leiden kunt u uw hele leven lang gebruik blijven maken van de Universitaire Bibliotheken Leiden (UBL).

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

Het Gorlaeus Gebouw wordt in drie fasen gerealiseerd. Het nieuwe gebouw is medio 2028 helemaal gereed.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.

Persoonlijke briefjes uit middeleeuws Rusland? We kennen wel veel officiële en kerkelijke documenten, maar de vondsten van stukjes beschreven berkenbast uit Novgorod geven op een unieke wijze inzicht in hoe 'gewone' mensen dagelijks met elkaar communiceerden.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua