Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Security and safety challenges rank among the most pressing issues of modern times. Challenges such as cyber-crime, terrorism, and environmental disasters impact the lives of millions across the globe. The course will introduce you to this broad theme in an increasingly complex world.

Urbanisation is steadily increasing with estimates expecting that 68% of the global population will live in cities by 2050. To accommodate the rural to urban transition, large quantities of land are transformed from natural to urban lands.

Verbinden van wetenschap en praktijk: opleidingen die jouw leiderschap en impact versterken.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Lorenza Colzato wil onderzoeken of het gebruik van probiotica en tryptofaan de sociaal-cognitieve achteruitgang die optreedt bij het ouder worden, kan vertragen. Daarvoor ontvangt Colzato samen met haar collega's in Duitsland en Spanje een JPI 'A Healthy Diet for A Healthy Life' Joint Transnational…

Het thema 'Health and well-being in a healthy society' is één van de speerpunten van de Faculteit der Sociale Wetenschappen (FSW). We zetten ons in voor het bevorderen van gezondheid en welzijn voor mensen van alle leeftijden.

De Raad van State heeft een programma van reflectie opgesteld, waarmee de hoogste bestuursrechter zijn aandeel in de kindertoeslagaffaire wil evalueren om lessen uit de affaire te kunnen trekken.

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Op dinsdag 24 maart is het boek 'The European Public Servant: A shared Administrative Identity?' verschenen.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotor: Prof.dr. P. Stevenhagen

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

Op 14 november organiseerde het Team Strategie & Verbinding van het DG Migratie van het Ministerie van Justitie en Veiligheid de jaarlijks de State of the Art conferentie. De conferentie brengt wetenschappers, beleidsmakers en andere professionals in het migratiedomein bijeen rond belangrijke migratievraagstukken.…

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Kunst en vrije tijd, Kunst en vrije tijd

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Het boek gaat in op de vraag: Hoe en waarom raken mensen betrokken bij het Europese 'homegrown jihadisme'?

Congres/symposium

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Het Leiden University Centre for the Arts in Society (LUCAS) is wereldwijd een van de weinige onderzoeksinstituten waar wetenschappers op het gebied van literatuur, beeldende kunst, architectuur, design en mediastudies samenkomen om onderzoek te doen naar de culturele productie van de westerse wereld,…

Per 20 augustus gaat universitair hoofddocent Michiel Tjepkema aan de slag bij de directie Bestuursrechtspraak van de Raad van State. Hij wordt het eerste hoofd van de kennisunit.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.