Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Lees hoe je je aanmeldt voor de MSc International Organisation aan Universiteit Leiden – inclusief stappen via Studielink, documenten indienen en vervolgstappen.

Volg de stapsgewijze aanmeldprocedure voor de MSc Nederlandse Politiek aan Universiteit Leiden: begin in Studielink, vervolg via uSis, dien je toelatingsverzoek in en registreer je na toelating.

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Promotor: R. Cramer

Volume 72 of the Netherlands Yearbook for History of Art is dedicated to the relationship of art and death in the Low Countries and its diaspora, from premodern times to the present. The editors welcome contributions on works of art and architecture (paintings, prints, sculptures, objects of applied…

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

Statistical distributions in LCA and converting between different representations of these distributions.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Human language is constantly evolving with its linguistic structure being shaped by language users at both individual and population levels. Focusing on the interplay between processes of language acquisition and communicative need in shaping human languages, this thesis introduces a novel computational…

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Raymond Fagel heeft eind december 2013 de NWO Vrije Competitie subsidie toegekend gekregen voor zijn project 'Facing the Enemy. The Spanish Army Commanders during the First Decade of the Dutch Revolt (1567-1577)'.

Op 17 november 2021 verdedigde Cyril-Igor Grigorieff het proefschrift 'The Regime for International Air Carrier Liability'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof.dr. V. Correia (University Paris Saclay).

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

The Grotius Centre for International Legal Studies is offering two internships on a full-time basis in spring 2019.

Studenten van Leiden University College werken samen met studenten uit Gaza en Myanmar om via storytelling de sociale determinanten van gezondheid te verkennen en inzichten te delen over ongelijkheid en veerkracht.

Cardiovascular syndromes are the major cause of death in Western societies.

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

Sinds de oprichting is LUC een college voor onderwijsontwikkeling en experimentatie. In de missie van het college wordt LUC beschreven als "een plek van innovatie op het gebied van didactiek, curriculumontwerp en studentwelzijn." Deze visie wordt toegepast via een studentgerichte benadering in het onderwijs…

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

De Iraakse archeologische site Nimrud werd kort geleden terugveroverd op IS. Maar wat nu te doen met de beschadigde resten? Bleda Düring sprak erover in Trouw.

This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

We verwelkomen gastwetenschappers wier onderzoek aansluit bij onze uiteenlopende expertisegebieden. De tekst gaat verder in het Engels.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Promotie

Lezing, LIMS seminar

Lezing

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Promotor: K.H. Kuijken

In this thesis, we study systems of electrons in which strong correlations give rise to emergent exotic physics.

Het Leiden University College The Hague gaat in september 2010 van start. In de aanloop naar de opening houdt het LUCTH een open dag op maandag 7 december. Dean Chris Goto-Jones stelt het College aan u voor.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: J. Zaanen, Co-Promotor: V. Juricic

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.