Risk has become one of the defining features of modern society. This course examines various types of safety and security risks, and how these are perceived and dealt with in a wide array of professional and academic fields, ranging from criminology, counter-terrorism and cyber security, to philosophy,…

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.

De maatschappelijke betrokkenheid van studenten en medewerkers van Leiden University College (LUC) reikt verder dan Den Haag. Met field courses, samenwerkingsverbanden en adviesrollen richten projecten zich op urgente kwesties zoals klimaatverandering, nepnieuws en sociale ongelijkheid.

Wie houdt er niet van een goed verhaal? Bij Film- en literatuurwetenschap onderzoek je de verhalen áchter de verhalen: van romans tot poëzie en van film tot nieuwe media. Hoe identificeren we ons met personages in boeken en films? En hoe en waarom wordt identificatie juist lastig gemaakt? In Leiden…

Promotor: Prof.dr. M.A.G.J. Orrit

Dynamical systems describe the evolution of objects in a space over time and may be used to model physical phenomena. Due to this, much research is dedicated to understanding the mathematics of dynamical systems.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

In the Schouwburgstraat, LUGO is currently redesigning the back-garden in order to increase biodiversity and make it a more beautiful space. Throughout October 2023 until March 2024, we will be making changes to the garden with our team of volunteers.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotor: Prof.dr. G.R. de Snoo

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

This dissertation explores how we can make anomaly detection—identifying unusual or faulty behavior in complex systems—more trustworthy and effective, with a focus on smart manufacturing.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Aan het LUCL pogen onderzoekers om de taaldiversiteit van de inheemse bevolking van Amerika te begrijpen, te bestuderen en te behouden.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

The upscaling of Life Cycle Assessment (LCA) data is recognized as one of the main challenges in the ex-ante LCA of emerging technologies. This challenge arises since industrial-scale system specifications for these technologies are unknown and industrial data is lacking.

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Understanding how nature captures and transfers solar energy is essential both for elucidating biological photosynthesis and for guiding the design of artificial light-harvesting systems.

This thesis was embedded in the APELAFICO project and focussed on investigating effects of sound from North Sea offshore wind farms on pelagic fish and harbour porpoise.

A series of workshops at Leiden University and the University of Hamburg will act as a forum in which international legal scholars whose research adopts a behavioural approach can present their works-in-progress and gain feedback from a broad range of peers, including scholars in economics and cognitive…

Kiemproject: Hoe kunnen metaforen bijdragen aan betere maatschappelijke betrokkenheid bij quantumwetenschap en -technologie, en welke factoren beïnvloeden de acceptatie of weerstand tegen metaforen bij zowel experts als leken?

Het Leiden University College The Hague heeft het zegel 'Topopleiding' ontvangen van de Keuzegids Universiteiten 2021. Het is de achtste keer op rij dat het Liberal Arts & Sciences- programma, dat zich richt op Global Challenges, het predicaat krijgt.

Het Leiden University College The Hague heeft het zegel 'Topopleiding' ontvangen van de Keuzegids Universiteiten 2022. Het is de negende keer op rij dat het Liberal Arts & Sciences- programma, dat zich richt op Global Challenges, het predicaat ontvangt.

Sinds 2009 behaalden 95 kandidaten hun doctoraat in Creative en Performing Arts. Op deze pagina een overzicht van ACPA's alumni.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

How did colonial law work to turn people into property? This project argues that colonial ideas about households and domestic authority were critical to legal processes of enslavement in the early modern Dutch empire. Using colonial court records from Dutch Brazil, Suriname, and the Moluccas, the project…

The studies in this thesis are focused on the physical effects in the flat band materials. The results contain the discovery of strong enhancement of RKKY spin-spin interactions with specific geometric arrangement and dynamical generation of excitonic order parameter with high magnitude.

This thesis consists of two subjects, that are both a consequence of radiation pressure.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Promotores: Prof.dr. D. Bouwmeester, Prof.dr. A. Fiore (TU Eindhoven)

Promotor: P. Stevenhagen, Co-promotor: R.M. van Luijk

Terugblik over de laatste 40 jaar op de belangrijkste veranderingen in de zorg en onderzoek, waar transparantie, verantwoording en richtlijn centraal zijn komen te staan. Aan de hand van de ziekte van Huntington en het cerebrovasculaire accident worden belangrijke veranderingen in de zorg en het onderzoek…

This thesis investigates the structural evolution and assembly of galaxies since the first few billions years after the big bang.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Gamic Learning in East Asian Studies - Wat kunnen spellen ons vertellen over de manier waarop mensen leren?

Wat maakte het vroege islamitische rijk zo succesvol en hebben we het verhaal gemist door cruciaal bewijs te negeren? De Arabische veroveringen in de 7e eeuw veranderden de sociaal-politieke configuraties in het Middellandse Zeegebied en Eurazië voorgoed. Toch weten we niet echt hoe de Arabieren erin…

Ontdek de cursus Communicating in Legal English van de Leiden Law Academy en verbeter uw juridisch Engelse vaardigheden. Lees hier meer!