The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

Promotor: T.H. Oosterkamp

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Galaxies form and live inside dark matter haloes. As a consequence, they are exposed to the tidal fields generated by the surrounding matter distribution: this imprints a preferential direction to the galaxy shapes, which leads to a coherent alignment on physically close galaxies, called intrinsic a…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Promotor: Prof.dr. M. Ubbink

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

Promotor: Prof.dr. A. Achucarro

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Promotor: Prof.dr. T. Schmidt

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Single-layer graphene (SLG) has attracted considerable interest as a proton exchange membrane for direct methanol fuel cells (DMFCs), owing to its atomic thickness, mechanical robustness, and unique proton permeability.

Een internationaal onderzoeksteam metgedragsbioloog Katharina Riebel als hoofdonderzoeker en twee internationale medewerkers ontving een Human Frontier Science Program (HFSP) beurs voor het hun onderzoeksvoorstel ‘Seeing voices’: the role of multimodal cues in vocal learning.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Congres/symposium

Promotor: P.M. Brakefield

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Volgens mij moeten we hierheen. Hierheen! HIER! HEEN!! Je verstaanbaar maken in een stad is soms lastig. Dat geldt niet alleen voor mensen: ook vogels blijken last te hebben van het omgevingsgeluid. Eerder bewees onderzoeker Hans Slabbekoorn al dat Leidse mezen anders communiceren in de stad. Nu blijkt…

Wilt u als professional ook de vruchten plukken van de onderwijsproeftuin? Lees dan verder voor ons aanbod van 'mixed classrooms'. U heeft ook de mogelijkheid om met de Honours Academy zelf onderwijs te organiseren.

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De wiskundemeisjes Jeanine Daems en Ionica Smeets komen op televisie. Vanaf donderdag 15 november, op Nederland 2, van 9.30 - 9.45 uur, zijn ze zes afleveringen lang te zien in de school-tv serie 'Wiskunde voor de tweede fase'.

Je kent haar waarschijnlijk van haar blog 'Wiskundemeisjes', Zomergasten (2014) of van haar columns in de Volkskrant en Kek Mama.

Deze week staat Weekblad Donald Duck in het teken van wiskunde en dat viert het blad met een speciale gast. Hoogleraar Wetenschapscommunicatie Ionica Smeets is namelijk te zien als Pionica Smeets, voorzitster van de Duckstadse Algebra-ver1niging.

Binnen de eerste subsidieronde van het NWO-onderzoeksprogramma Complexity is het project 'Critical transitions and early-warning signals in spatial ecosystems', gezamenlijk ingediend door Arjen Doelman, Jens Rademacher (CWI) en Max Rietkerk en Martin Wassen (beiden geowetenschappen, UU), gehonoreerd…