513 zoekresultaten voor “genome organisation” in de Publieke website
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
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New dimensions of the cellular response to DNA damage
Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.
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Sculpting the genome and beyond
Promotie
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Dynamic organization of bacterial chromatin by DNA bridging proteins
Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.
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Internship information
An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.
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The dynamic organization of prokaryotic genomes
Promotie
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Functional study of the human genome
Promotie
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CRISPR Cas-induced targeted mutagenesis with Agrobacterium mediated protein delivery
The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.
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On the origin of ‘bloopergenes’: unraveling the evolution of the balanced lethal system in Triturus newts
This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.
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Neotropical bat species: an exploration of brain morphology and genetics
In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.
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Career
The field of science communication is very broad. Below is a list of organisations where SCS students can fulfill internships or where alumni have found jobs.
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Over de opleiding
Je gaat specifieke vakken volgen zoals International Organisations en Actors in World Politics. Maar je verdiept je ook in meer algemene thema’s, zoals International Politics, Comparative Politics en Global History. Ook werk je aan je academische en professionele vaardigheden.
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Toelating en aanmelding
De specialisatie International Relations and Organisations geniet een grote populariteit. Om de kwaliteit van het onderwijs te waarborgen, is het aantal studenten dat wordt toegelaten beperkt. Dit staat bekend als een ‘numerus fixus’.
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Na je studie
Als je International Relations and Organisations studeert, lijkt het alsof de tijd vliegt. Gelukkig geeft deze specialisatie je een ideale basis voor een vervolgopleiding en een professionele carrière.
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Chat met een student
Heb je een vraag over het studentenleven Den Haag, studeren aan de Universiteit Leiden of wil je meer informatie over International Relations and Organisations? Je kunt direct in contact komen met een student!
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Contact
Heb je een vraag over studeren aan de Universiteit Leiden? Of over de specialisatie International Relations and Organisations? Neem gerust contact met ons op!
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Conflict, Conflict Resolution and Crisis Management
Het onderzoekscluster ‘Conflict, Conflict Resolution and Crisis Management’ maakt deel uit van het onderzoeksprogramma ‘Institutions, Decisions and Collective Behaviour’. De betrokken onderzoekers bestuderen hoe politieke conflicten ontstaan en welke typen crises we kunnen onderscheiden. Hoe hanteren…
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Representation and Political Parties
‘Representation and Political Parties’ is een van de zeven onderzoeksclusters binnen het programma ‘Institutions, Decisions and Collective Behaviour’. De aangesloten onderzoekers richten zich op de rol die burgers spelen binnen een democratie en op de vertegenwoordiging van kiezers door politici.
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Legitimacy and Justice
‘Legitimacy and Justice’ is een onderzoekscluster binnen het programma ‘Institutions, Decisions and Collective Behaviour’. De wetenschappers die hierin actief zijn houden zich bezig met de legitimiteit en rechtvaardigheid van politieke instituties. Zij kijken in het bijzonder naar de relaties tussen…
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European Integration
Deze onderzoekscluster maakt deel uit van het onderzoeksprogramma ‘Institutions, Decisions and Collective Behaviour’.
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Elections, Communication and Public Opinion
Dit onderzoekscluster maakt deel uit van het onderzoeksprogramma ‘Institutions, Decisions and Collective Behaviour’.
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Institutions, Decisions and Collective Behaviour
Het onderzoek dat wordt gedaan binnen het Instituut Politieke Wetenschap heeft als gemene deler dat er vanuit verschillende politicologische sub-disciplines wordt gekeken naar de dynamiek van en wisselwerking tussen politieke instituties, individuele besluitvorming en collectief gedrag.
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Politics in the Netherlands
Binnen het onderzoeksprogramma ‘Institutions, Decisions and Collective Behaviour’ richt het onderzoekscluster ‘Politics in the Netherlands’ zich op de Nederlandse politiek. De onderzoekers bestuderen de opzet en het functioneren van de politieke instituties en kijken naar de attitudes en het gedrag…
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Identity, Ethnicity and Political Community
Binnen het onderzoeksprogramma ‘Institutions, Decisions and Collective Behaviour’ richt het onderzoekscluster ‘Identity, Ethnicity and Political Community’ zich op vraagstukken rondom identiteit en diversiteit. De betrokken onderzoekers bestuderen zaken als migratie, immigratie, burgerschap, integratie,…
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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Algorithms for the description of molecular sequences
Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros
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Group benefits from genomic instability: a tale of antibiotic warriors in Streptomyces
Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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Comparative genomics of the balanced lethal system in Triturus newts
All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?
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Improving targeted gene editing in Arabidopsis thaliana
Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…
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Exploring Grainyhead-like 2 target genes in breast cancer
The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.
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Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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Contributions to the phylogeny of the haplolepideous mosses
The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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Ecological functions and environmental fate of exopolymers of Acidobacteria
Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.
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Forever Young: How AHL15 delays developmental phase transitions to prevent ageing in plants
The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.
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Politicologie (BSc)
Politicologie is een brede studie met veel diepgang. Je bestudeert politieke vraagstukken op lokaal, nationaal en internationaal niveau, vanuit verschillende invalshoeken.
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Safeguarding genome integrity with small ubiquitin-like modifers
Promotie
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Student for a Day at International Relations and Organisations
› Engelstalige aankondiging van dit evenement
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Diploma uitreiking BSc Political Science International Relations and Organisations
Festival
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Diploma-uitreiking BSc Political Science International Relations and Organisations
Festival
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Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
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International courts in an era of smartphones and social media – improving human rights accountability?
Wat zijn de effecten van digitalisering op de internationale rechtspraak?
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Democratie beschermen in de Europese Unie
Het is niet langer vanzelfsprekend dat de EU-lidstaten stabiele democratieën zijn. Wat moet de EU doen om de democratie te beschermen, gezien het toenemende democratische verval in sommige lidstaten?