Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Roy de Winter heeft op 2 juni de G. Rosenberg Research Award van het Leiden Institute of Advanced Computer Science (LIACS) gewonnen. De Winter kreeg de award uitgereikt tijdens de viering van het 25-jarig bestaan van het LIACS. De nieuwe award is bedoeld voor veelbelovende promovendi van het LIACS.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram

IoT technology poses serval opportunities to supply chains. This thesis employs grey correlation and forecasting models, system dynamics, agent-based modeling, and ex-ante LCA to investigate and quantify the opportunities and risks of IoT-enabled sustainable supply chain operations from both industrial…

This thesis advances automata learning, a key area in computer science, with applications in software verification, biological analysis, and autonomous technologies. It explores three main themes: first, it introduces a passive learning algorithm for generating compact probabilistic models from positive…

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: Prof.dr. K.J. Batenburg

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Op maandag 19 mei 2025 organiseert Website Application Services van het ISSC in samenwerking met SC&M een Webinar Universitaire Website[s]. Tijdens dit online web event wordt je o.a. ge-update over diverse inhoudelijke zaken die voor jou als webredacteur belangrijk kunnen zijn! Ga via deze link…

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Op maandag 19 mei 2025 organiseert Website Application Services van het ISSC in samenwerking met SC&M een Webinar Universitaire Website[s]. Tijdens dit online web event wordt je o.a. ge-update over diverse inhoudelijke zaken die voor jou als webredacteur belangrijk kunnen zijn! Ga via deze link…

Promotie

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Promotor: Prof.dr. M. Ubbink

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Promotor: M.A.G.J. Orrit

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Computers worden steeds krachtiger en krijgen steeds ingewikkelder taken. Het Leiden Institute of Advanced Computer Science (LIACS) doet baanbrekend wetenschappelijk onderzoek en past nieuwe vindingen toe in actuele maatschappelijke vraagstukken.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Leiden Institute of Advanced Computer Science (LIACS)

Promotie