This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

In this thesis we classify the pairs (p,G), where p is a prime number and G is a finite p-group possessing an intense automorphism, i.e. an automorphism that sends each subgroup of G to a G-conjugate, that is non-trivial and whose order is coprime to p.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Promotor: Prof.dr. S. Portegies Zwart

Promotor: Prof.dr. H.J.A. Rottgering

In this thesis integral points on affine del Pezzo surfaces are studied.

In this thesis, we develop a novel technique called Optical Near-field Electron Microscopy (ONEM), which aims to combine the advantages of both optical and electron microscopy: the high resolution of electron microscopy and the low sample damage of optical microscopy.

Promotor: Bas Edixhoven, Promotor: Qing Liu

Promotor: J. Kuiper

Promotor: Prof.dr. P.C. van Welzen

Promotores: T.H. Oosterkamp, N. de Jonge

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

The vegetative growth period for leafy vegetables like lettuce is essential for yield and quality.

The monograph

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Onderzoekers van LIACS werken aan het bedenken van de computers van morgen die de ruggengraat zullen vormen van de Cloud en Edge computing paradigma’s en ‘the Internet of Things’. In dit verband zijn we betrokken bij onderzoek en ontwikkeling van high performance computing systemen, embedded & real-time…

Psychologielab op Wielen is mogelijk dankzij de steun van onze partners.

Het faciliteren van directe burgerparticipatie via onlinekanalen wordt gezien als een kans om lastig bereikbare groepen bij de participatie te betrekken

Around the world, mindfulness has become big business. This course combines conventional scholarly inquiry from multiple disciplines with experiential learning to provide a responsible, comprehensive, and inclusive education about mindfulness as a contemporary phenomenon.

In this course, you will learn about sustainability and staying with the environmental boundaries of our planet. You will gain an understanding of the effects of growing affluence and population growth, the key challenges we are facing, and ways to influence your direct environment.

This thesis is about the study of hydrocarbons via infrared spectroscopy.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

The expanding population and economic activity are driving up global energy consumption. Simultaneously, there is an urgent need to transition from fossil fuels to renewable sources to mitigate the climate crisis, primarily caused by fossil fuel combustion.

Reconstructie van de taalgeschiedenis door onderzoek naar taalverandering.

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

DSE 2.0: Naar een optimaal ontwerp van complexe, gedistribueerde cyber-fysieke systemen

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Promotor: Roeland M.H. Merks

Overzicht van de belangrijkste papyrologische websites

Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Including modelling as part of software development appears to have various benefits.